5CEK Chain A
Tribbles homolog 1 (TRIB1)
Inactive — 1.1%DFG-outαC-in
Resolution
2.8 Å
R-value
0.209
Predicted activity confidence1.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues3
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
PSRIADYLLLPLAHVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDALSCPAYVSPEILNTTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVL
UniProt reference sequence
YLLLPLAEREHVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWF
Aligned reference sequence
YLLL----------------PLA------ERE-------------HVSRALC--IH------------------------------------TGRELRCKVFP--IKHY------------------------------QDKIRPYIQLPSHS-----------------------------NITGIVEVILGET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KAYVFFEKDF---------------GDMHSYVRS--RK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLREEEAARLFKQIVSAVAHCHQS---------------------------------------------AIVLGDL-----KLRKFVFST--EE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTQLRLESLEDTHIMKGEDDA--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDKHGCPAYVSPEILNT--T-----------------------------GTYSGKAADVWSLGVMLYTLLVG-----------------RYPFHD--------------------------------------------------SDPSALFSKIRRG--QFCIPEHIS------------------------------------------------------------------------------------------------------PKARCLIRSLLRREPSERLT--------------APEILLHPWF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YLLL----------------PLA----------------------HVSRALC--IH------------------------------------TGRELRCKVFP--IKHY------------------------------QDKIRPYIQLPSHS-----------------------------NITGIVEVILGET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KAYVFFEKDF---------------GDMHSYVRS--RK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLREEEAARLFKQIVSAVAHCHQS---------------------------------------------AIVLGDL-----KLRKFVFST--EE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTQLRLESLE---------DA--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S----CPAYVSPEILNT---------------------------------TYSGKAADVWSLGVMLYTLLVG-----------------RYPFHD--------------------------------------------------SDPSALFSKIRRG--QFCIPEHIS------------------------------------------------------------------------------------------------------PKARCLIRSLLRREPSERLT--------------APEILLHPWF
Activation segment
SLE---------DA--L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S----CPAYVSPE
Binding pocket
LLLPLA___HVSRLRCKVFYQDKIRPYIQLPSSNITGIVEVYVFFEKDF_GDMHSYVRSHCHQSAIVLGDLKLRKFVFLRLESLE
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5CEK, Chain A