5BYZ Chain A
Mitogen-activated protein kinase 7 (MAPK7)
Active — 99.9%DFG-inαC-inType1 · 4WE
Resolution
1.65 Å
R-value
0.175
Predicted activity confidence99.9%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
TFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGI
UniProt reference sequence
YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL
Aligned reference sequence
YEII----------------ETIGNGA----------------YGVVSSARR--RL------------------------------------TGQQVAIKKIP--NAFDVVTN--------------------------AKRTLRELKILKHF--------------------------KHDNIIAIKDILRPTV--PYGEFK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYVVLDLME---------------SDLHQIIHS--SQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLTLEHVRYFLYQLLRGLKYMHSA---------------------------------------------QVIHRDL-----KPSNLLVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCELKIGDFGMARGLCTSPAE--HQYFM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPELMLS--L-----------------------------HEYT-QAIDLWSVGCIFGEMLAR-----------------RQLFPG--------------------------------------------------KNYVHQLQLIMMV--LGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGAD-----------------------------------------------------------------------RQALSLLGRMLRFEPSARIS--------------AAAALRHPFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEII----------------ETIGNGA----------------YGVVSSARR--RL------------------------------------TGQQVAIKKIP--NAFDVVTN--------------------------AKRTLRELKILKHF--------------------------KHDNIIAIKDILRPTV--PYGEFK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYVVLDLME---------------SDLHQIIHS--SQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLTLEHVRYFLYQLLRGLKYMHSA---------------------------------------------QVIHRDL-----KPSNLLVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCELKIGDFGMARGLCTSPAE--HQYFM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPELMLS--L-----------------------------HEYT-QAIDLWSVGCIFGEMLAR-----------------RQLFPG--------------------------------------------------KNYVHQLQLIMMV--LGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGAD-----------------------------------------------------------------------RQALSLLGRMLRFEPSARIS--------------AAAALRHPFL
Activation segment
DFGMARGLCTSPAE--HQYFM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPE
Binding pocket
ETIGNGAYGVVSSVAIKKIRTLRELKILKHFKDNIIAIKDIYVVLDLME_SDLHQIIHSYMHSAQVIHRDLKPSNLLVIGDFGMA
Ligand info
Orthosteric ligand
4WE
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5BYZ, Chain A