5B2M Chain A
Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)
Inactive — 0.0%DFG-outαC-out
Resolution
3.06 Å
R-value
0.291
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues7
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
YLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFAGCAAYMAPERIDPPRADVWSLGISLVELATGQFPYVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAK
UniProt reference sequence
LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFI
Aligned reference sequence
LENL----------------GEMGSGT----------------CGQVWKMRF--RK------------------------------------TGHVIAVKQMR--RSGNKEE---------------------------NKRILMDLDVVLKS--H-----------------------DCPYIVQCFGTFITNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVFIAMELMG---------------TCAEKLKKR--MQG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIPERILGKMTVAIVKALYYLKEK--H------------------------------------------GVIHRDV-----KPSNILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGQIKLCDFGISGRLVDSKAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRSAGCAAYMAPERIDP--PDPTK-------------------------PDYD-IRADVWSLGISLVELATG-----------------QFPYKN--C-----------------------------------------------KTDFEVLTKVLQE--EPPLLPGHMGFS---------------------------------------------------------------------------------------------------GDFQSFVKDCLTKDHRKRPK--------------YNKLLEHSFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LENL----------------GEMGSGT----------------CGQVWKMRF--RK------------------------------------TGHVIAVKQMR--RSGN------------------------------------DLDVVLKS--H-----------------------DCPYIVQCFGTFITNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVFIAMELMG---------------TCAEKLKKR--MQG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIPERILGKMTVAIVKALYYLKEK--H------------------------------------------GVIHRDV-----KPSNILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGQIKLCDF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGCAAYMAPERIDP--P-----------------------------------RADVWSLGISLVELATG-----------------QFPY---------------------------------------------------------VLTKVLQE--EPPLLPGHMGFS---------------------------------------------------------------------------------------------------GDFQSFVKDCLTKDHRKRPK--------------YNKLLEHSFI
Activation segment
DF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGCAAYMAPE
Binding pocket
GEMGSGTCGQVWKIAVKQM____DLDVVLKSHPYIVQCFGTFIAMELMGTCAEKLKKRMLKEKHGVIHRDVKPSNILLLCDF___
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5B2M, Chain A