5AR8 Chain A
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)
Inactive — 0.0%DFG-inαC-outType1.5_Back · XYW
Resolution
2.79 Å
R-value
0.204
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms13
Missing residues5
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLLREAEILHKARFSYILPILGICNLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGTIIYMPPENYASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK
UniProt reference sequence
LADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEP
Aligned reference sequence
LADL----------------RYLSRGA----------------SGTVSSARH--AD------------------------------------WRVQVAVKHLH--IHTPLLDSE-------------------------RKDVLREAEILHKA--------------------------RFSYILPILGICNEPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLGIVTEYMPN--------------GSLNELLHR--KTEYP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVAWPLRFRILHEIALGVNYLHNM--TP-----------------------------------------PLLHHDL-----KTQNILLDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFHVKIADFGLSKWRMMSLSQ--SRSSKS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APEGGTIIYMPPENYEP--GQK---------------------------SRAS-IKHDIYSYAVITWEVLSR-----------------KQPFED--V-----------------------------------------------TNPLQIMYSVSQG--HRPVINEESLPYDIPHR----------------------------------------------------------------------------------------------ARMISLIESGWAQNPDERPS--------------FLKCLIELEP
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LADL----------------RYLSRGA----------------SGTVSSARH--AD------------------------------------WRVQVAVKHL-----------------------------------------LREAEILHKA--------------------------RFSYILPILGICN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGIVTEYMPN--------------GSLNELLHR--KTEYP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVAWPLRFRILHEIALGVNYLHNM--TP-----------------------------------------PLLHHDL-----KTQNILLDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFHVKIADF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTIIYMPPENY------------------------------------AS-IKHDIYSYAVITWEVLSR-----------------KQPFED--V-----------------------------------------------TNPLQIMYSVSQG--HRPVINEESLPYDIPHR----------------------------------------------------------------------------------------------ARMISLIESGWAQNPDERPS--------------FLKCLIELEP
Activation segment
DF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTIIYMPPE
Binding pocket
RYLSRGASGTVSSVAVKHL__LREAEILHKARSYILPILGIGIVTEYMPNGSLNELLHRHNMTPPLLHHDLKTQNILLIADF___
Ligand info
Orthosteric ligand
XYW
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5AR8, Chain A