5AR3 Chain B
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)
Active — 95.0%DFG-inαC-inATPlike · ACP
Resolution
3.23 Å
R-value
0.192
Predicted activity confidence95.0%
Structure info
Alternate conformationA
Missing atoms6
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
ICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMTIIYMPPENYEPASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK
UniProt reference sequence
LADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEP
Aligned reference sequence
LADL----------------RYLSRGA----------------SGTVSSARH--AD------------------------------------WRVQVAVKHLH--IHTPLLDSE-------------------------RKDVLREAEILHKA--------------------------RFSYILPILGICNEPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLGIVTEYMPN--------------GSLNELLHR--KTEYP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVAWPLRFRILHEIALGVNYLHNM--TP-----------------------------------------PLLHHDL-----KTQNILLDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFHVKIADFGLSKWRMMSLSQ--SRSSKS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APEGGTIIYMPPENYEP--GQK---------------------------SRAS-IKHDIYSYAVITWEVLSR-----------------KQPFED--V-----------------------------------------------TNPLQIMYSVSQG--HRPVINEESLPYDIPHR----------------------------------------------------------------------------------------------ARMISLIESGWAQNPDERPS--------------FLKCLIELEP
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LADL----------------RYLSRGA----------------SGTVSSARH--AD------------------------------------WRVQVAVKHLH----------E-------------------------RKDVLREAEILHKA--------------------------RFSYILPILGICNEPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLGIVTEYMPN--------------GSLNELLHR--KTEYP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVAWPLRFRILHEIALGVNYLHNM--TP-----------------------------------------PLLHHDL-----KTQNILLDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFHVKIADFGLSKWRM----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIIYMPPENYEP----------------------------------AS-IKHDIYSYAVITWEVLSR-----------------KQPFED--V-----------------------------------------------TNPLQIMYSVSQG--HRPVINEESLPYDIPHR----------------------------------------------------------------------------------------------ARMISLIESGWAQNPDERPS--------------FLKCLIELEP
Activation segment
DFGLSKWRM----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIIYMPPE
Binding pocket
RYLSRGASGTVSSVAVKHLDVLREAEILHKARSYILPILGIGIVTEYMPNGSLNELLHRHNMTPPLLHHDLKTQNILLIADFGLS
Ligand info
Orthosteric ligand
ACP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5AR3, Chain B