5A6N Chain A
Death-associated protein kinase 3 (DAPK3)
Inactive — 49.3%DFG-inαC-inType1 · U7E
Resolution
1.7 Å
R-value
0.184
Predicted activity confidence49.3%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
MVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAI
UniProt reference sequence
YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWI
Aligned reference sequence
YEMG----------------EELGSGQ----------------FAIVRKCRQ--KG------------------------------------TGKEYAAKFIK--KRRLSSSRRGVS----------------------REEIEREVNILREI--------------------------RHPNIITLHDIFENKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVVLILELVSG--------------GELFDFLAE--KE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTEDEATQFLKQILDGVHYLHSK---------------------------------------------RIAHFDL-----KPENIMLLD--KNVP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRIKLIDFGIAHKIEAGNEF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNIFGTPEFVAPEIVNY--------------------------------EPLG-LEADMWSIGVITYILLSG-----------------ASPFLG--------------------------------------------------ETKQETLTNISAV--NYDFDEEYFSNTS--------------------------------------------------------------------------------------------------ELAKDFIRRLLVKDPKRRMT--------------IAQSLEHSWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEMG----------------EELGSGQ----------------FAIVRKCRQ--KG------------------------------------TGKEYAAKFIK--KRRLSSSRRGVS----------------------REEIEREVNILREI--------------------------RHPNIITLHDIFENKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVVLILELVSG--------------GELFDFLAE--KE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTEDEATQFLKQILDGVHYLHSK---------------------------------------------RIAHFDL-----KPENIMLLD--KNVP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRIKLIDFGIAHKIEAGNEF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNIFGTPEFVAPEIVNY--------------------------------EPLG-LEADMWSIGVITYILLSG-----------------ASPFLG--------------------------------------------------ETKQETLTNISAV--NYDFDEEYFSNTS--------------------------------------------------------------------------------------------------ELAKDFIRRLLVKDPKRRMT--------------IAQSLEHSWI
Activation segment
DFGIAHKIEAGNEF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNIFGTPEFVAPE
Binding pocket
EELGSGQFAIVRKYAAKFIEIEREVNILREIRPNIITLHDIVLILELVSGGELFDFLAEYLHSKRIAHFDLKPENIMLLIDFGIA
Ligand info
Orthosteric ligand
U7E
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 5A6N, Chain A