4ZTL Chain D
Interleukin-1 receptor-associated kinase 4 (IRAK4)
Active — 99.6%DFG-inαC-inType1 · 4S1
Resolution
2.39 Å
R-value
0.226
Predicted activity confidence99.6%
Structure info
Alternate conformationA
Missing atoms2
Missing residues1
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
RFHSFSFYELKNVTNNFDERPISVGGNKMGEGFGVVYKGYVNNTTVAVKKLAATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEVMRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
UniProt reference sequence
NVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQE
Aligned reference sequence
NVT---NNFDERPISVGG--NKMGEGG----------------FGVVYKGYV----------------------------------------NNTTVAVKKLA--AMVDITTEEL------------------------KQQFDQEIKVMAKC--------------------------QHENLVELLGFSSDGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLCLVYVYMPN--------------GSLLDRLSC--LDGTP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN---------------------------------------------HHIHRDI-----KSANILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFTAKISDFGLARASEKFAQT--VMT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRIVGTTAYMAPEALR---------------------------------GEIT-PKSDIYSFGVVLLEIITG-----------------LPAVDE--HREP--------------------------------------------QLLLDIKEEIEDE--EKTIEDYIDKKMNDADSTSV-------------------------------------------------------------------------------------------EAMYSVASQCLHEKKNKRPD--------------IKKVQQLLQE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
NVT---NNFDERPISVGG--NKMGE-G----------------FGVVYKGYV----------------------------------------NNTTVAVKKLA--A----TTEEL------------------------KQQFDQEIKVMAKC--------------------------QHENLVELLGFSSDGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLCLVYVYMPN--------------GSLLDRLSC--LDGTP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN---------------------------------------------HHIHRDI-----KSANILLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFTAKISDFGLARASE-------VM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIVGTTAYMAPEALR---------------------------------GEIT-PKSDIYSFGVVLLEIITG-----------------LPAVDE--HREP--------------------------------------------QLLLDIKEEIEDE--EKTIEDYIDKKMNDADSTSV-------------------------------------------------------------------------------------------EAMYSVASQCLHEKKNKRPD--------------IKKVQQLLQE
Activation segment
DFGLARASE-------VM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIVGTTAYMAPE
Binding pocket
NKMGEG_FGVVYKVAVKKLQFDQEIKVMAKCQENLVELLGFCLVYVYMPNGSLLDRLSCFLHENHHIHRDIKSANILLISDFGLA
Ligand info
Orthosteric ligand
4S1
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4ZTL, Chain D