4ZSJ Chain A
Mitogen-activated protein kinase 7 (MAPK7)
Active — 99.8%DFG-inαC-inType3 · 4R0
Resolution
2.48 Å
R-value
0.17
Predicted activity confidence99.8%
Structure info
Alternate conformationB
Missing atoms3
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
DVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARRE
UniProt reference sequence
YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL
Aligned reference sequence
YEII----------------ETIGNGA----------------YGVVSSARR--RL------------------------------------TGQQVAIKKIP--NAFDVVTN--------------------------AKRTLRELKILKHF--------------------------KHDNIIAIKDILRPTV--PYGEFK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYVVLDLME---------------SDLHQIIHS--SQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLTLEHVRYFLYQLLRGLKYMHSA---------------------------------------------QVIHRDL-----KPSNLLVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCELKIGDFGMARGLCTSPAE--HQYFM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPELMLS--L-----------------------------HEYT-QAIDLWSVGCIFGEMLAR-----------------RQLFPG--------------------------------------------------KNYVHQLQLIMMV--LGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGAD-----------------------------------------------------------------------RQALSLLGRMLRFEPSARIS--------------AAAALRHPFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEII----------------ETIGNGA----------------YGVVSSARR--RL------------------------------------TGQQVAIKKIP--NAFDVVTN--------------------------AKRTLRELKILKHF--------------------------KHDNIIAIKDILRPTV--PYGEFK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYVVLDLME---------------SDLHQIIHS--SQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLTLEHVRYFLYQLLRGLKYMHSA---------------------------------------------QVIHRDL-----KPSNLLVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCELKIGDFGMARGLCTSPAE--HQYFM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPELMLS--L-----------------------------HEYT-QAIDLWSVGCIFGEMLAR-----------------RQLFPG--------------------------------------------------KNYVHQLQLIMMV--LGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGAD-----------------------------------------------------------------------RQALSLLGRMLRFEPSARIS--------------AAAALRHPFL
Activation segment
DFGMARGLCTSPAE--HQYFM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPE
Binding pocket
ETIGNGAYGVVSSVAIKKIRTLRELKILKHFKDNIIAIKDIYVVLDLME_SDLHQIIHSYMHSAQVIHRDLKPSNLLVIGDFGMA
Ligand info
Orthosteric ligand
4R0
Allosteric ligand
None
Ligand typeType3
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4ZSJ, Chain A