4ZSG Chain A
Mitogen-activated protein kinase 7 (MAPK7)
Active — 99.9%DFG-inαC-inType3 · 4QX
Resolution
1.79 Å
R-value
0.206
Predicted activity confidence99.9%
Structure info
Alternate conformationA
Missing atoms2
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARRE
UniProt reference sequence
YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL
Aligned reference sequence
YEII----------------ETIGNGA----------------YGVVSSARR--RL------------------------------------TGQQVAIKKIP--NAFDVVTN--------------------------AKRTLRELKILKHF--------------------------KHDNIIAIKDILRPTV--PYGEFK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYVVLDLME---------------SDLHQIIHS--SQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLTLEHVRYFLYQLLRGLKYMHSA---------------------------------------------QVIHRDL-----KPSNLLVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCELKIGDFGMARGLCTSPAE--HQYFM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPELMLS--L-----------------------------HEYT-QAIDLWSVGCIFGEMLAR-----------------RQLFPG--------------------------------------------------KNYVHQLQLIMMV--LGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGAD-----------------------------------------------------------------------RQALSLLGRMLRFEPSARIS--------------AAAALRHPFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEII----------------ETIGNGA----------------YGVVSSARR--RL------------------------------------TGQQVAIKKIP--NAFDVVTN--------------------------AKRTLRELKILKHF--------------------------KHDNIIAIKDILRPTV--PYGEFK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYVVLDLME---------------SDLHQIIHS--SQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLTLEHVRYFLYQLLRGLKYMHSA---------------------------------------------QVIHRDL-----KPSNLLVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCELKIGDFGMARGLCTSPAE--HQYFM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPELMLS--L-----------------------------HEYT-QAIDLWSVGCIFGEMLAR-----------------RQLFPG--------------------------------------------------KNYVHQLQLIMMV--LGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGAD-----------------------------------------------------------------------RQALSLLGRMLRFEPSARIS--------------AAAALRHPFL
Activation segment
DFGMARGLCTSPAE--HQYFM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYVATRWYRAPE
Binding pocket
ETIGNGAYGVVSSVAIKKIRTLRELKILKHFKDNIIAIKDIYVVLDLME_SDLHQIIHSYMHSAQVIHRDLKPSNLLVIGDFGMA
Ligand info
Orthosteric ligand
4QX
Allosteric ligand
None
Ligand typeType3
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4ZSG, Chain A