4ZHX Chain C
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)
Active — 99.7%DFG-inαC-inType1,Allosteric · 4O7
Resolution
2.99 Å
R-value
0.226
Predicted activity confidence99.7%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQGLPSYLFPEDPSYDANVIDDEAVKEVCECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSSAMHIPPGLKPHPERMPPLIAAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA
UniProt reference sequence
YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF
Aligned reference sequence
YVLG----------------DTLGVGT----------------FGKVKIGEH--QL------------------------------------TGHKVAVKILN--RQKIRSLDV-------------------------VGKIKREIQNLKLF--------------------------RHPHIIKLYQVISTPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFFMVMEYVSG--------------GELFDYICK--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVEEMEARRLFQQILSAVDYCHRH---------------------------------------------MVVHRDL-----KPENVLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMNAKIADFGLSNMMSDGEFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTSCGSPNYAAPEVISG--------------------------------RLYAGPEVDIWSCGVILYALLCG-----------------TLPFDD--------------------------------------------------EHVPTLFKKIRGG--VFYIPEYLN------------------------------------------------------------------------------------------------------RSVATLLMHMLQVDPLKRAT--------------IKDIREHEWF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YVLG----------------DTLGVGT----------------FGKVKIGEH--QL------------------------------------TGHKVAVKILN--RQKIRSLDV-------------------------VGKIKREIQNLKLF--------------------------RHPHIIKLYQVISTPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFFMVMEYVSG--------------GELFDYICK--HG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVEEMEARRLFQQILSAVDYCHRH---------------------------------------------MVVHRDL-----KPENVLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMNAKIADFGLSNMMSDGEFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-SCGSPNYAAPEVISG--------------------------------RLYAGPEVDIWSCGVILYALLCG-----------------TLPFDD--------------------------------------------------EHVPTLFKKIRGG--VFYIPEYLN------------------------------------------------------------------------------------------------------RSVATLLMHMLQVDPLKRAT--------------IKDIREHEWF
Activation segment
DFGLSNMMSDGEFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-SCGSPNYAAPE
Binding pocket
DTLGVGTFGKVKIVAVKILKIKREIQNLKLFRPHIIKLYQVFMVMEYVSGGELFDYICKYCHRHMVVHRDLKPENVLLIADFGLS
Ligand info
Orthosteric ligand
4O7
Allosteric ligand
C1V
Ligand typeType1,Allosteric
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4ZHX, Chain C