4Z55 Chain A
ALK tyrosine kinase receptor (ALK)
Inactive — 13.7%DFG-inαC-inType1 · 4LO
Resolution
1.55 Å
R-value
0.185
Predicted activity confidence13.7%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
NPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRAGYYKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPI
UniProt reference sequence
ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEY
Aligned reference sequence
ITLI----------------RGLGHGA----------------FGEVYEGQV--SGMPNDP-------------------------------SPLQVAVKTLP--EVCSEQD---------------------------ELDFLMEALIISKF--------------------------NHQNIVRCIGVSLQSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRFILLELMAG--------------GDLKSFLRE--TRPRPSQPS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLAMLDLLHVARDIACGCQYLEEN---------------------------------------------HFIHRDI-----AARNCLLTC--PGP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRVAKIGDFGMARDIYRASYY--RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCAMLPVKWMPPEAFME--------------------------------GIFT-SKTDTWSFGVLLWEIFSL--G--------------YMPYPS--------------------------------------------------KSNQEVLEFVTSG--GRMDPPKNCP-----------------------------------------------------------------------------------------------------GPVYRIMTQCWQHQPEDRPN--------------FAIILERIEY
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLI----------------RGLGHGA----------------FGEVYEGQV----------------------------------------SPLQVAVKTLP--EVCSEQD---------------------------ELDFLMEALIISKF--------------------------NHQNIVRCIGVSLQSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRFILLELMAG--------------GDLKSFLRE--TRPRP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAMLDLLHVARDIACGCQYLEEN---------------------------------------------HFIHRDI-----AARNCLLTC--PGP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRVAKIGDFGMARDIYRAGYY---KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCAMLPVKWMPPEAFME--------------------------------GIFT-SKTDTWSFGVLLWEIFSL--G--------------YMPYPS--------------------------------------------------KSNQEVLEFVTSG--GRMDPPKNCP-----------------------------------------------------------------------------------------------------GPVYRIMTQCWQHQPEDRPN--------------FAIILERIEY
Activation segment
DFGMARDIYRAGYY---KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCAMLPVKWMPPE
Binding pocket
RGLGHGAFGEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA
Ligand info
Orthosteric ligand
4LO
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4Z55, Chain A