4Z16 Chain A
Tyrosine-protein kinase JAK3 (JAK3)
Inactive — 0.0%DFG-inαC-inType1 · 4LH
Resolution
2.9 Å
R-value
0.204
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYELRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDVVRPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR
UniProt reference sequence
LEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNS
Aligned reference sequence
LEWH----------------ENLGHGS----------------FTKIYRGCR--HEVVDGEA------------------------------RKTEVLLKVMD--AKHKNC----------------------------MESFLEAASLMSQV--------------------------SYRHLVLLHGVCMAG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSTMVQEFVHL--------------GAIDMYLRK--RGH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVPASWKLQVVKQLAYALNYLEDK---------------------------------------------GLPHGNV-----SARKVLLAR--EGADGS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPFIKLSDPGVSPAVLSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMLTDRIPWVAPECLRE--A-----------------------------QTLS-LEADKWGFGATVWEVFSG--V--------------TMPISA--------------------------------------------------LDPAKKLQFYEDR--QQLPAPKW-------------------------------------------------------------------------------------------------------TELALLIQQCMAYEPVQRPS--------------FRAVIRDLNS
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKYI----------------SQLGKGN----------------F-GSVELCR-----YDPLG------------------------------DNTGALVAVKQ--LQHFQR----------------------------EIQILKALHSDFIV--------------------------KYR------GV--SY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELRLVMEYLPS--------------GCLRDFLQR--HRA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLDASRLLLYSSQICKGMEYL------------------------------------------------------G-----SRRCVLAAR--NILVES------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EAHVKIADFG-LAKLLPL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DKDVVRIFWYAPESL-S--D-----------------------------NIFS-RQSDVWSFGVVLYELFSA--E--------------FLRMMA--------------------------------------------------L--CRLLELLEEG--QRLPAPCP-------------------------------------------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS--------------FSALGPQLSR
Activation segment
DFG-LAKLLPL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DKDVVRIFWYAPE
Binding pocket
SQLGKGNFGSVELVAVKQLDFQREIQILKALHDFIVKYRGVRLVMEYLPSGCLRDFLQRYLGSRRCVHRDLAARNILVIADFGLA
Ligand info
Orthosteric ligand
4LH
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4Z16, Chain A