4YOM Chain B
Serine/threonine-protein kinase BRSK2 (BRSK2)
Inactive — 0.1%DFG-inαC-out
Resolution
2.49 Å
R-value
0.199
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
HAQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKLE
UniProt reference sequence
YRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWY
Aligned reference sequence
YRLE----------------KTLGKGQ----------------TGLVKLGVH--CV------------------------------------TCQKVAIKIVN--REKLSESV--------------------------LMKVEREIAILKLI--------------------------EHPHVLKLHDVYENKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYLVLEHVSG--------------GELFDYLVK--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLTPKEARKFFRQIISALDFCHSH---------------------------------------------SICHRDL-----KPENLLLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNNIRIADFGMASLQVGDSLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETSCGSPHYACPEVIRG--------------------------------EKYDGRKADVWSCGVILFALLVG-----------------ALPFDD--------------------------------------------------DNLRQLLEKVKRG--VFHMPHFIP------------------------------------------------------------------------------------------------------PDCQSLLRGMIEVDAARRLT--------------LEHIQKHIWY
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YRLE----------------KTLGKGQ----------------TGLVKLGIH--CV------------------------------------TCQKVAIKIVN--REKLSESV--------------------------LMKVEREIAILKLI--------------------------EHPHVLKLHDVYENKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYLVLEHVSG--------------GELFDYLVK--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLTPKEARKFFRQIISALDFCHSH---------------------------------------------SICHRDL-----KPENLLLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RNNIRIADFGMASLQVGDSLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETSCGSPHYACPEVIRG--------------------------------EKYDGRKADVWSCGVILFALLVG-----------------ALPFDD--------------------------------------------------DNLRQLLEKVKRG--VFHMPHFIP------------------------------------------------------------------------------------------------------PDCQSLLRGMIEVDAARRLT--------------LEHIQKHIWY
Activation segment
DFGMASLQVGDSLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETSCGSPHYACPE
Binding pocket
KTLGKGQTGLVKLVAIKIVKVEREIAILKLIEPHVLKLHDVYLVLEHVSGGELFDYLVKFCHSHSICHRDLKPENLLLIADFGMA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4YOM, Chain B