4YNZ Chain A
Serine/threonine-protein kinase BRSK2 (BRSK2)
Inactive — 0.0%DFG-inαC-out
Resolution
2.0 Å
R-value
0.192
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GPLGSMQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDERNNIRIADFGMASLQSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKL
UniProt reference sequence
YRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWY
Aligned reference sequence
YRLE----------------KTLGKGQ----------------TGLVKLGVH--CV------------------------------------TCQKVAIKIVN--REKLSESV--------------------------LMKVEREIAILKLI--------------------------EHPHVLKLHDVYENKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYLVLEHVSG--------------GELFDYLVK--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLTPKEARKFFRQIISALDFCHSH---------------------------------------------SICHRDL-----KPENLLLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNNIRIADFGMASLQVGDSLL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETSCGSPHYACPEVIRG--------------------------------EKYDGRKADVWSCGVILFALLVG-----------------ALPFDD--------------------------------------------------DNLRQLLEKVKRG--VFHMPHFIP------------------------------------------------------------------------------------------------------PDCQSLLRGMIEVDAARRLT--------------LEHIQKHIWY
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YRLE----------------KTLGKGQ----------------TGLVKLGIH--CV------------------------------------TCQKVAIKIVN--REKLSESV--------------------------LMKVEREIAILKLI--------------------------EHPHVLKLHDVYENKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYLVLEHVSG--------------GELFDYLVK--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLTPKEARKFFRQIISALDFCHSH---------------------------------------------SICHRDL-----KPENLLLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RNNIRIADFGMASLQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPHYACPEVIRG--------------------------------EKYDGRKADVWSCGVILFALLVG-----------------ALPFDD--------------------------------------------------DNLRQLLEKVKRG--VFHMPHFIP------------------------------------------------------------------------------------------------------PDCQSLLRGMIEVDAARRLT--------------LEHIQKHIWY
Activation segment
DFGMASLQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPHYACPE
Binding pocket
KTLGKGQTGLVKLVAIKIVKVEREIAILKLIEPHVLKLHDVYLVLEHVSGGELFDYLVKFCHSHSICHRDLKPENLLLIADFGMA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4YNZ, Chain A