4YMJ Chain A
NT-3 growth factor receptor (NTRK3)
Inactive — 18.7%DFG-outαC-outType1 · 4EJ
Resolution
2.0 Å
R-value
0.166
Predicted activity confidence18.7%
Structure info
Alternate conformationA
Missing atoms12
Missing residues2
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GIHVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGDVYTDYYRHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKAT
UniProt reference sequence
IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHA
Aligned reference sequence
IVLK----------------RELGEGA----------------FGKVFLAEC--YNLSPTK-------------------------------DKMLVAVKALK--DPTLAA----------------------------RKDFQREAELLTNL--------------------------QHEHIVKFYGVCGDGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLIMVFEYMKH--------------GDLNKFLRA--HGPDAMILVDGQPRQAKG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELGLSQMLHIASQIASGMVYLASQ---------------------------------------------HFVHRDL-----ATRNCLVGA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLLVKIGDFGMSRDVYSTDYY--RLFNPSGNDFCIWCEVG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHTMLPIRWMPPESIMY--------------------------------RKFT-TESDVWSFGVILWEIFTY--G--------------KQPWFQ--------------------------------------------------LSNTEVIECITQG--RVLERPRVCP-----------------------------------------------------------------------------------------------------KEVYDVMLGCWQREPQQRLN--------------IKEIYKILHA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IVLK----------------RELGEGA----------------FGKVFLAEC--YNLSPTK-------------------------------DKMLVAVKALK--DPTLAA----------------------------RKDFQREAELLTNL--------------------------QHEHIVKFYGVCGDGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLIMVFEYMKH--------------GDLNKFLRA--HGP--------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELGLSQMLHIASQIASGMVYLASQ---------------------------------------------HFVHRDL-----ATRNCLVGA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLLVKIGDFG---DVY-TDYY--R----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HTMLPIRWMPPESIMY--------------------------------RKFT-TESDVWSFGVILWEIFTY--G--------------KQPWFQ--------------------------------------------------LSNTEVIECITQG--RVLERPRVCP-----------------------------------------------------------------------------------------------------KEVYDVMLGCWQREPQQRLN--------------IKEIYKILHA
Activation segment
DFG---DVY-TDYY--R----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HTMLPIRWMPPE
Binding pocket
RELGEGAFGKVFLVAVKALDFQREAELLTNLQEHIVKFYGVIMVFEYMKHGDLNKFLRAYLASQHFVHRDLATRNCLVIGDFG__
Ligand info
Orthosteric ligand
4EJ
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4YMJ, Chain A