4YFF Chain C
Serine/threonine-protein kinase TNNI3K (TNNI3K)
Inactive — 4.5%DFG-inαC-inType1 · 4CV
Resolution
3.07 Å
R-value
0.211
Predicted activity confidence4.5%
Structure info
Alternate conformationA
Missing atoms22
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCN
UniProt reference sequence
IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEE
Aligned reference sequence
IEFH----------------EIIGSGS----------------FGKVYKGRC----------------------------------------RNKIVAIKRYR--ANTYCSKSD-------------------------VDMFCREVSILCQL--------------------------NHPCVIQFVGACLNDP--S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFAIVTQYISG--------------GSLFSLLHE--QKR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILDLQSKLIIAVDVAKGMEYLHNL--TQ-----------------------------------------PIIHRDL-----NSHNILLYE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHAVVADFGESRFLQSLDED--NM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKQPGNLRWMAPEVFTQ--C-----------------------------TRYT-IKADVFSYALCLWEILTG-----------------EIPFAH--------------------------------------------------LKPAAAAADMAYH--HIRPPIGYSIP----------------------------------------------------------------------------------------------------KPISSLLIRGWNACPEGRPE--------------FSEVVMKLEE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IEFH----------------EIIGSGS----------------FGKVYKGRC----------------------------------------RNKIVAIKRY----------SD-------------------------VDMFCREVSILCQL--------------------------NHPCVIQFVGACLNDP--S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFAIVTQYISG--------------GSLFSLLHE--QKR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILDLQSKLIIAVDVAKGMEYLHNL--TQ-----------------------------------------PIIHRDL-----NSHNILLYE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHAVVADFGESRFLQS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPGNLRWMAPEVFTQ--C-----------------------------TRYT-IKADVFSYALCLWEILTG-----------------EIPFAH--------------------------------------------------LKPAAAAADMAYH--HIRPPIGYSIP----------------------------------------------------------------------------------------------------KPISSLLIRGWNACPEGRPE--------------FSEVVMKLEE
Activation segment
DFGESRFLQS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPGNLRWMAPE
Binding pocket
EIIGSGSFGKVYKVAIKRYMFCREVSILCQLNPCVIQFVGAAIVTQYISGGSLFSLLHEHNLTQPIIHRDLNSHNILLVADFGES
Ligand info
Orthosteric ligand
4CV
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4YFF, Chain C