4YC3 Chain A
Cyclin-dependent kinase 1 (CDK1)
Active — 62.3%DFG-inαC-in
Resolution
2.7 Å
R-value
0.214
Predicted activity confidence62.3%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
UniProt reference sequence
YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
Aligned reference sequence
YTKI----------------EKIGEGT----------------YGVVYKGRH--KT------------------------------------TGQVVAMKKIR--LESEEEGV--------------------------PSTAIREISLLKEL--------------------------RHPNIVSLQDVLMQDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLYLIFEFLS---------------MDLKKYLDS--IPPGQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSR---------------------------------------------RVLHRDL-----KPQNLLIDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGTIKLADFGLARAFGIPIRV--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THEVVTLWYRSPEVLLG--S-----------------------------ARYS-TPVDIWSIGTIFAELATK-----------------KPLFHG--------------------------------------------------DSEIDQLFRIFRA--LGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLD-------------------------------------------------------------------------ENGLDLLSKMLIYDPAKRIS--------------GKMALNHPYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YTKI----------------EKIGEGT----------------YGVVYKGRH--KT------------------------------------TGQVVAMKKIR--LESEEEGV--------------------------PSTAIREISLLKEL--------------------------RHPNIVSLQDVLMQDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLYLIFEFLS---------------MDLKKYLDS--IPPGQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSR---------------------------------------------RVLHRDL-----KPQNLLIDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGTIKLADFGLARAFGIPIRV--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T---VTLWYRSPEVLLG--S-----------------------------ARYS-TPVDIWSIGTIFAELATK-----------------KPLFHG--------------------------------------------------DSEIDQLFRIFRA--LGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLD-------------------------------------------------------------------------ENGLDLLSKMLIYDPAKRIS--------------GKMALNHPYF
Activation segment
DFGLARAFGIPIRV--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T---VTLWYRSPE
Binding pocket
EKIGEGTYGVVYKVAMKKITAIREISLLKELRPNIVSLQDVYLIFEFLS_MDLKKYLDSFCHSRRVLHRDLKPQNLLILADFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4YC3, Chain A