4Y72 Chain A
Cyclin-dependent kinase 1 (CDK1)
Active — 94.5%DFG-inαC-inType1 · LZ9
Resolution
2.3 Å
R-value
0.19
Predicted activity confidence94.5%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LGSMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND
UniProt reference sequence
YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
Aligned reference sequence
YTKI----------------EKIGEGT----------------YGVVYKGRH--KT------------------------------------TGQVVAMKKIR--LESEEEGV--------------------------PSTAIREISLLKEL--------------------------RHPNIVSLQDVLMQDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLYLIFEFLS---------------MDLKKYLDS--IPPGQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSR---------------------------------------------RVLHRDL-----KPQNLLIDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGTIKLADFGLARAFGIPIRV--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THEVVTLWYRSPEVLLG--S-----------------------------ARYS-TPVDIWSIGTIFAELATK-----------------KPLFHG--------------------------------------------------DSEIDQLFRIFRA--LGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLD-------------------------------------------------------------------------ENGLDLLSKMLIYDPAKRIS--------------GKMALNHPYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YTKI----------------EKIGEGT----------------YGVVYKGRH--KT------------------------------------TGQVVAMKKIR--LESEEEGV--------------------------PSTAIREISLLKEL--------------------------RHPNIVSLQDVLMQDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLYLIFEFLS---------------MDLKKYLDS--IPPGQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSR---------------------------------------------RVLHRDL-----KPQNLLIDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGTIKLADFGLARAFGIPIRV--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THEVVTLWYRSPEVLLG--S-----------------------------ARYS-TPVDIWSIGTIFAELATK-----------------KPLFHG--------------------------------------------------DSEIDQLFRIFRA--LGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLD-------------------------------------------------------------------------ENGLDLLSKMLIYDPAKRIS--------------GKMALNHPYF
Activation segment
DFGLARAFGIPIRV--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THEVVTLWYRSPE
Binding pocket
EKIGEGTYGVVYKVAMKKITAIREISLLKELRPNIVSLQDVYLIFEFLS_MDLKKYLDSFCHSRRVLHRDLKPQNLLILADFGLA
Ligand info
Orthosteric ligand
LZ9
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4Y72, Chain A