4XV3 Chain B
Serine/threonine-protein kinase B-raf (BRAF)
Inactive — 0.0%DFG-inαC-in
Resolution
2.8 Å
R-value
0.26
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues8
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DDWEIPDGQITVGQRIGVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHTVKIGDFATEGSILWMAPEVINPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELA
UniProt reference sequence
ITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIEL
Aligned reference sequence
ITVG----------------QRIGSGS----------------FGTVYKGKW-----------------------------------------HGDVAVKMLN--VTAPTPQQ--------------------------LQAFKNEVGVLRKT--------------------------RHVNILLFMGYSTKP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLAIVTQWCEG--------------SSLYHHLHI--IET------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFEMIKLIDIARQTAQGMDYLHAK---------------------------------------------SIIHRDL-----KSNNIFLHE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTVKIGDFGLATVKSRWSGS--HQF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQLSGSILWMAPEVIRM--QDK---------------------------NPYS-FQSDVYAFGIVLYELMTG-----------------QLPYSN--I-----------------------------------------------NNRDQIIFMVGRG--YLSPDLSKVRSNCP-------------------------------------------------------------------------------------------------KAMKRLMAECLKKKRDERPL--------------FPQILASIEL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITVG----------------QRIG----------------------VYKGKW-----------------------------------------HGDVAVKMLN--VTAPTPQQ--------------------------LQAFKNEVGVLRKT--------------------------RHVNILLFMGYST------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAIVTQWCEG--------------SSLYHHLHA--SET------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFEMKKLIDIARQTARGMDYLHAK---------------------------------------------SIIHRDL-----KSNNIFLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVKIGDF--AT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGSILWMAPEVI----------------------------------NPYS-FQSDVYAFGIVLYELMTG-----------------QLPYSN--I-----------------------------------------------NNRDQIIEMVGRG--SLSPDLSKVRSNCP-------------------------------------------------------------------------------------------------KRMKRLMAECLKKKRDERPS--------------FPRILAEIEA
Activation segment
DF--AT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGSILWMAPE
Binding pocket
QRIG______VYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQWCEGSSLYHHLHAYLHAKSIIHRDLKSNNIFLIGDF__A
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4XV3, Chain B