4XUF Chain A
Receptor-type tyrosine-protein kinase FLT3 (FLT3)
Inactive — 2.1%DFG-outαC-inType2 · P30
Resolution
3.2 Å
R-value
0.299
Predicted activity confidence2.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKESSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKRLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQL
UniProt reference sequence
LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGC
Aligned reference sequence
LEFG----------------KVLGSGA----------------FGKVMNATA--YGISKTG-------------------------------VSIQVAVKMLK--EKADSSE---------------------------REALMSELKMMTQL--G-----------------------SHENIVNLLGACTLSG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYLIFEYCCY--------------GDLLNYLRS--KREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLTFEDLLCFAYQVAKGMEFLEFK---------------------------------------------SCVHRDL-----AARNVLVTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKVVKICDFGLARDIMSDSNY--VVR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPESLFE--------------------------------GIYT-IKSDVWSYGILLWEIFSL--G--------------VNPYPG--I-----------------------------------------------PVDANFYKLIQNG--FKMDQPFYAT-----------------------------------------------------------------------------------------------------EEIYIIMQSCWAFDSRKRPS--------------FPNLTSFLGC
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LEFG----------------KVLGSGA----------------FGKVMNATA--YGISKTG-------------------------------VSIQVAVKMLK--E---SSE---------------------------REALMSELKMMTQL--G-----------------------SHENIVNLLGACTLSG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYLIFEYCCY--------------GDLLNYLRS--KR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTFEDLLCFAYQVAKGMEFLEFK---------------------------------------------SCVHRDL-----AARNVLVTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKVVKICDFGLARDIMSDSNY--VVR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPESLFE--------------------------------GIYT-IKSDVWSYGILLWEIFSL--G--------------VNPYPG--I-----------------------------------------------PVDANFYKLIQNG--FKMDQPFYAT-----------------------------------------------------------------------------------------------------EEIYIIMQSCWAFDSRKRPS--------------FPNLTSFLGC
Activation segment
DFGLARDIMSDSNY--VVR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPE
Binding pocket
KVLGSGAFGKVMNVAVKMLALMSELKMMTQLGENIVNLLGAYLIFEYCCYGDLLNYLRSFLEFKSCVHRDLAARNVLVICDFGLA
Ligand info
Orthosteric ligand
P30
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4XUF, Chain A