4X7Q Chain B
Serine/threonine-protein kinase pim-2 (PIM2)
Active — 97.5%DFG-inαC-inType1 · 3YR
Resolution
2.33 Å
R-value
0.199
Predicted activity confidence97.5%
Structure info
Alternate conformation—
Missing atoms19
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
AFEAEYRLGPLLGKGFGTVFAGHRLTDRLQVAIKVIPRCPLEVALLWKVGAGGGHPGVIRLLDWFETFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQ
UniProt reference sequence
YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWM
Aligned reference sequence
YRLG----------------PLLGKGG----------------FGTVFAGHR--LT------------------------------------DRLQVAIKVIP--RNRVLGWSPLSD----------------------SVTCPLEVALLWKV--GAGG--------------------GHPGVIRLLDWFETQE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFMLVLERPLP--A-----------QDLFDYITE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGEGPSRCFFGQVVAAIQHCHSR---------------------------------------------GVVHRDI-----KDENILIDL--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGCAKLIDFGSGALLHDEPY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDFDGTRVYSPPEWISR--------------------------------HQYHALPATVWSLGILLYDMVCG-----------------DIPFE--------------------------------------------------------RDQEILEA--ELHFPAHVS------------------------------------------------------------------------------------------------------PDCCALIRRCLAPKPSSRPS--------------LEEILLDPWM
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YRLG----------------PLLGK-G----------------FGTVFAGHR--LT------------------------------------DRLQVAIKVIP--R------------------------------------CPLEVALLWKV--GAGG--------------------GHPGVIRLLDWFET-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FMLVLERPLP--A-----------QDLFDYITE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLGEGPSRCFFGQVVAAIQHCHSR---------------------------------------------GVVHRDI-----KDENILIDL--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGCAKLIDFGSGALLHDEPY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDFDGTRVYSPPEWISR--------------------------------HQYHALPATVWSLGILLYDMVCG-----------------DIPFE--------------------------------------------------------RDQEILEA--ELHFPAHVS------------------------------------------------------------------------------------------------------PDCCALIRRCLAPKPSSRPS--------------LEEILLDPWM
Activation segment
DFGSGALLHDEPY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDFDGTRVYSPPE
Binding pocket
PLLGKG_FGTVFAVAIKVI_CPLEVALLWKVGPGVIRLLDWMLVLERPLAQDLFDYITEHCHSRGVVHRDIKDENILILIDFGSG
Ligand info
Orthosteric ligand
3YR
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4X7Q, Chain B