4X7O Chain A
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
Inactive — 0.0%DFG-inαC-outType1 · 3Z6
Resolution
2.65 Å
R-value
0.2
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms12
Missing residues4
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
YISRYLTDFEPIQCLGRGGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRNLKPSNIFFTMDDVVKVGDFGTKLYMSPEQIHYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLD
UniProt reference sequence
FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVF
Aligned reference sequence
FEPI----------------QCLGRGG----------------FGVVFEAKN--KV------------------------------------DDCNYAIKRIR--LPNRELA---------------------------REKVMREVKALAKL--------------------------EHPGIVRYFNAWLEAP--PEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKV--YLYIQMQLCRK--------------ENLKDWMNG--RCTIE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERERSVCLHIFLQIAEAVEFLHSK---------------------------------------------GLMHRDL-----KPSNIFFTM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDVVKVGDFGLVTAMDQDEEE--QTVLTPMPAYARH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGQVGTKLYMSPEQIHG--------------------------------NSYS-HKVDIFSLGLILFELLYP-------------------------FSTQ--------------------------------------------MERVRTLTDVRNL--KFPPLFTQKY-----------------------------------------------------------------------------------------------------PCEYVMVQDMLSPSPMERPE--------------AINIIENAVF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEPI----------------QCLGRG------------------GVVFEAKN--KV------------------------------------DDCNYAIKRIR--LPNRELA---------------------------REKVMREVKALAKL--------------------------EHPGIVRYFNAWLEAP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PKV--YLYIQMQLCRK--------------ENLKDWMNG--RCTIE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERERSVCLHIFLQIAEAVEFLHSK---------------------------------------------GLMHRNL-----KPSNIFFTM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDVVKVGDF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTKLYMSPEQIH-----------------------------------YS-HKVDIFSLGLILFELLYP-------------------------FSTQ--------------------------------------------MERVRTLTDVRNL--KFPPLFTQKY-----------------------------------------------------------------------------------------------------PCEYVMVQDMLSPSPMERPE--------------AINIIENAVF
Activation segment
DF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTKLYMSPE
Binding pocket
QCLGRGG__VVFEYAIKRIKVMREVKALAKLEPGIVRYFNAYIQMQLCRKENLKDWMNGFLHSKGLMHRNLKPSNIFFVGDFG__
Ligand info
Orthosteric ligand
3Z6
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4X7O, Chain A