4X3J Chain A
Angiopoietin-1 receptor (TEK)
Inactive — 0.0%DFG-outαC-outType2 · 3WR
Resolution
2.5 Å
R-value
0.257
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues19
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
VLKARMDAAIKELEVLCKLGHHPNIINLLLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRNLAARNILVGENYVAKIADFGLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGID
UniProt reference sequence
IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNR
Aligned reference sequence
IKFQ----------------DVIGEGN----------------FGQVLKARI--KKDG----------------------------------LRMDAAIKRMK--EYASKDD---------------------------HRDFAGELEVLCKL--G-----------------------HHPNIINLLGACEHRG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLYLAIEYAPH--------------GNLLDFLRK--SRVLETDPAFAIANSTAS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSSQQLLHFAADVARGMDYLSQK---------------------------------------------QFIHRDL-----AARNILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYVAKIADFGLSRGQEVYVKK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMGRLPVRWMAIESLNY--------------------------------SVYT-TNSDVWSYGVLLWEIVSL--G--------------GTPYCG--------------------------------------------------MTCAELYEKLPQG--YRLEKPLNCD-----------------------------------------------------------------------------------------------------DEVYDLMRQCWREKPYERPS--------------FAQILVSLNR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
----------------------------------------------VLKA-------------------------------------------RMDAAIK---------------------------------------------ELEVLCKL--G-----------------------HHPNIINLL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LYLAIEYAPH--------------GNLLDFLRK--SRVLETDPAFAIANSTAS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLSSQQLLHFAADVARGMDYLSQK---------------------------------------------QFIHRNL-----AARNILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYVAKIADFG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPVRWMAIESLNY--------------------------------SVYT-TNSDVWSYGVLLWEIVSL--G--------------GTPYCG--------------------------------------------------MTCAELYEKLPQG--YRLEKPLNCD-----------------------------------------------------------------------------------------------------DEVYDLMRQCWREKPYERPS--------------FAQILVSLNR
Activation segment
DFG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPVRWMAIE
Binding pocket
__________VLKAAIK______ELEVLCKLGPNIINLL__YLAIEYAPHGNLLDFLRKYLSQKQFIHRNLAARNILVIADFGL_
Ligand info
Orthosteric ligand
3WR
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4X3J, Chain A