4X2F Chain A
TGF-beta receptor type-1 (TGFBR1)
Active — 99.9%DFG-inαC-inType1 · 3WJ
Resolution
1.49 Å
R-value
0.165
Predicted activity confidence99.9%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGI
UniProt reference sequence
IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQ
Aligned reference sequence
IVLQ----------------ESIGKGR----------------FGEVWRGKW----------------------------------------RGEEVAVKIFS--SRE-------------------------------ERSWFREAEIYQTV--ML----------------------RHENILGFIAADNKDN--GTWT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVSDYHEH--------------GSLFDYLNR--Y--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVTVEGMIKLALSTASGLAHLHME--IVGTQGKP-----------------------------------AIAHRDL-----KSKNILVKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGTCCIADLGLAVRHDSATDT--IDIAP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NHRVGTKRYMAPEVLDD--SINMKH------------------------FESF-KRADIYAMGLVFWEIARR--CSIGGIHEDY-----QLPYYD--LVPSD-------------------------------------------PSVEEMRKVVCEQ--KLRPNIPNRWQSCEAL-----------------------------------------------------------------------------------------------RVMAKIMRECWYANGAARLT--------------ALRIKKTLSQ
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IVLQ----------------ESIGKGR----------------FGEVWRGKW----------------------------------------RGEEVAVKIFS--SRE-------------------------------ERSWFREAEIYQTV--ML----------------------RHENILGFIAADNKDN--GTWT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVSDYHEH--------------GSLFDYLNR--Y--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVTVEGMIKLALSTASGLAHLHME--IVGTQGKP-----------------------------------AIAHRDL-----KSKNILVKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGTCCIADLGLAVRHDSATDT--IDIAP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NHRVGTKRYMAPEVLDD--SINMKH------------------------FESF-KRADIYAMGLVFWEIARR--CSIGGIHEDY-----QLPYYD--LVPSD-------------------------------------------PSVEEMRKVVCEQ--KLRPNIPNRWQSCEAL-----------------------------------------------------------------------------------------------RVMAKIMRECWYANGAARLT--------------ALRIKKTLSQ
Activation segment
DLGLAVRHDSATDT--IDIAP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NHRVGTKRYMAPE
Binding pocket
ESIGKGRFGEVWRVAVKIFSWFREAEIYQTVMENILGFIAAWLVSDYHEHGSLFDYLNRTQGKPAIAHRDLKSKNILVIADLGLA
Ligand info
Orthosteric ligand
3WJ
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4X2F, Chain A