4WUA Chain A
SRSF protein kinase 1 (SRPK1)
Active — 99.0%DFG-inαC-inType1 · 3UL
Resolution
2.0 Å
R-value
0.199
Predicted activity confidence99.0%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS
UniProt reference sequence
YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL
Aligned reference sequence
YHVI----------------RKLGWGH----------------FSTVWLSWD--IQ------------------------------------GKKFVAMKVVK--SAEHY-----------------------------TETALDEIRLLKSV--RNSDPNDP----------------NREMVVQLLDDFKISG--VNGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HICMVFEVLG---------------HHLLKWIIK--SNYQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPLPCVKKIIQQVLQGLDYLHTK--C------------------------------------------RIIHTDI-----KPENILLSV--NEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAE----------------------------------KLKVKIADLGNACWVHKHF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEDIQTRQYRSLEVLIG--------------------------------SGYN-TPADIWSTACMAFELATG-----------------DYLFEP--HSGEEY------------------------------------------TRDEDHIALIIEL--LGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEA------------------------------------------------------------AGFTDFLLPMLELIPEKRAT--------------AAECLRHPWL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YHVI----------------RKLGWGH----------------FSTVWLSWD--IQ------------------------------------GKKFVAMKVVK--SAEHY-----------------------------TETALDEIRLLKSV--RNSDPNDP----------------NREMVVQLLDDFKISG--VNGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HICMVFEVLG---------------HHLLKWIIK--SNYQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLPLPCVKKIIQQVLQGLDYLHTK--C------------------------------------------RIIHTDI-----KPENILLSV--NEQYIRRLAAEAT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VNPLEPKNAE----------------------------------KLKVKIADLGNACWVHKHF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEDIQTRQYRSLEVLIG--------------------------------SGYN-TPADIWSTACMAFELATG-----------------DYLFEP--HSGEEY------------------------------------------TRDEDHIALIIEL--LGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEA------------------------------------------------------------AGFTDFLLPMLELIPEKRAT--------------AAECLRHPWL
Activation segment
DLGNACWVHKHF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEDIQTRQYRSLE
Binding pocket
RKLGWGHFSTVWLVAMKVVTALDEIRLLKSVREMVVQLLDDCMVFEVLG_HHLLKWIIKLHTKCRIIHTDIKPENILLIADLGNA
Ligand info
Orthosteric ligand
3UL
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4WUA, Chain A