4WO5 Chain A
Serine/threonine-protein kinase B-raf (BRAF)
Inactive — 47.5%DFG-inαC-outType1.5_Back · 324
Resolution
2.83 Å
R-value
0.196
Predicted activity confidence47.5%
Structure info
Alternate conformation—
Missing atoms18
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASEKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSFEQLSGSILWMAPEVIRMNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL
UniProt reference sequence
ITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIEL
Aligned reference sequence
ITVG----------------QRIGSGS----------------FGTVYKGKW-----------------------------------------HGDVAVKMLN--VTAPTPQQ--------------------------LQAFKNEVGVLRKT--------------------------RHVNILLFMGYSTKP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLAIVTQWCEG--------------SSLYHHLHI--IET------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFEMIKLIDIARQTAQGMDYLHAK---------------------------------------------SIIHRDL-----KSNNIFLHE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTVKIGDFGLATVKSRWSGS--HQF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQLSGSILWMAPEVIRM--QDK---------------------------NPYS-FQSDVYAFGIVLYELMTG-----------------QLPYSN--I-----------------------------------------------NNRDQIIFMVGRG--YLSPDLSKVRSNCP-------------------------------------------------------------------------------------------------KAMKRLMAECLKKKRDERPL--------------FPQILASIEL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITVG----------------QRIGSGS----------------FGTVYKGKW-----------------------------------------HGDVAVKMLN--VTAPTPQQ--------------------------LQAFKNEVGVLRKT--------------------------RHVNILLFMGYSTKP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLAIVTQWCEG--------------SSLYHHLHA--SE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFEMKKLIDIARQTARGMDYLHAK---------------------------------------------SIIHRDL-----KSNNIFLHE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNTVKIGDFGLATVKSRWS------F-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQLSGSILWMAPEVIRM--------------------------------NPYS-FQSDVYAFGIVLYELMTG-----------------QLPYSN--I-----------------------------------------------NNRDQIIEMVGRG--SLSPDLSKVRSNCP-------------------------------------------------------------------------------------------------KRMKRLMAECLKKKRDERPS--------------FPRILAEIEL
Activation segment
DFGLATVKSRWS------F-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQLSGSILWMAPE
Binding pocket
QRIGSGSFGTVYKVAVKMLAFKNEVGVLRKTRVNILLFMGYAIVTQWCEGSSLYHHLHAYLHAKSIIHRDLKSNNIFLIGDFGLA
Ligand info
Orthosteric ligand
324
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4WO5, Chain A