4UY9 Chain A
Mitogen-activated protein kinase kinase kinase 9 (MAP3K9)
Inactive — 0.1%DFG-inαC-out
Resolution
2.81 Å
R-value
0.189
Predicted activity confidence0.1%
Structure info
Alternate conformationA
Missing atoms4
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
QLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTW
UniProt reference sequence
LTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTT
Aligned reference sequence
LTLE----------------EIIGIGG----------------FGKVYRAFW----------------------------------------IGDEVAVKAAR--HDPDEDISQT------------------------IENVRQEAKLFAML--------------------------KHPNIIALRGVCLKEP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLCLVMEFARG--------------GPLNRVLSG--K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIPPDILVNWAVQIARGMNYLHDE--AIV----------------------------------------PIIHRDL-----KSSNILILQ--KVENGDLS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKILKITDFGLAREWHRTTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSAAGTYAWMAPEVIRA--------------------------------SMFS-KGSDVWSYGVLLWELLTG-----------------EVPFRG--------------------------------------------------IDGLAVAYGVAMN--KLALPIPSTCP----------------------------------------------------------------------------------------------------EPFAKLMEDCWNPDPHSRPS--------------FTNILDQLTT
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LTLE----------------EIIGIGG----------------FGKVYRAFW----------------------------------------IGDEVAVKAAR--HDPDEDISQT------------------------IENVRQEAKLFAML--------------------------KHPNIIALRGVCLKEP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLCLVMEFARG--------------GPLNRVLSG--K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIPPDILVNWAVQIARGMNYLHDE--AIV----------------------------------------PIIHRDL-----KSSNILILQ--KVENGDLS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKILKITDFGLAREWHRTTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSAAGTYAWMAPEVIRA--------------------------------SMFS-KGSDVWSYGVLLWELLTG-----------------EVPFRG--------------------------------------------------IDGLAVAYGVAMN--KLALPIPSTCP----------------------------------------------------------------------------------------------------EPFAKLMEDCWNPDPHSRPS--------------FTNILDQLTT
Activation segment
DFGLAREWHRTTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSAAGTYAWMAPE
Binding pocket
EIIGIGGFGKVYRVAVKAANVRQEAKLFAMLKPNIIALRGVCLVMEFARGGPLNRVLSGDEAIVPIIHRDLKSSNILIITDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4UY9, Chain A