4USF Chain A
STE20-like serine/threonine-protein kinase (SLK)
Inactive — 0.0%DFG-outαC-inType1 · 6UI
Resolution
1.75 Å
R-value
0.198
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
SMKQYEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKTPYWMAPEVVMCERPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAE
UniProt reference sequence
WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV
Aligned reference sequence
WEII----------------GELGDGA----------------FGKVYKAQN--KE------------------------------------TSVLAAAKVID--TKSEEE----------------------------LEDYMVEIDILASC--------------------------DHPNIVKLLDAFYYEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLWILIEFCAG--------------GAVDAVMLE--LER------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDN---------------------------------------------KIIHRDL-----KAGNILFTL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGDIKLADFGVSAKNTRTIQR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSFIGTPYWMAPEVVMC--ETSKD-------------------------RPYD-YKADVWSLGITLIEMAEI-----------------EPPHHE--------------------------------------------------LNPMRVLLKIAKS--EPPTLAQPSRWS---------------------------------------------------------------------------------------------------SNFKDFLKKCLEKNVDARWT--------------TSQLLQHPFV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
WEII----------------GELGDGA----------------FGKVYKAQN--KE------------------------------------TSVLAAAKVID--TKSEEE----------------------------LEDYMVEIDILASC--------------------------DHPNIVKLLDAFYYEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLWILIEFCAG--------------GAVDAVMLE--LER------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDN---------------------------------------------KIIHRDL-----KAGNILFTL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGDIKLADFGVSAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPYWMAPEVVMC--E-----------------------------RPYD-YKADVWSLGITLIEMAEI-----------------EPPHHE--------------------------------------------------LNPMRVLLKIAKS--EPPTLAQPSRWS---------------------------------------------------------------------------------------------------SNFKDFLKKCLEKNVDARWT--------------TSQLLQHPFV
Activation segment
DFGVSAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPYWMAPE
Binding pocket
GELGDGAFGKVYKAAAKVIDYMVEIDILASCDPNIVKLLDAWILIEFCAGGAVDAVMLEYLHDNKIIHRDLKAGNILFLADFGVS
Ligand info
Orthosteric ligand
6UI
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4USF, Chain A