4USE Chain A
Serine/threonine-protein kinase 10 (STK10)
Inactive — 0.2%DFG-inαC-inType1 · R09
Resolution
2.65 Å
R-value
0.226
Predicted activity confidence0.2%
Structure info
Alternate conformationB
Missing atoms10
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
EHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVME
UniProt reference sequence
WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFV
Aligned reference sequence
WEIV----------------GELGDGA----------------FGKVYKAKN--KE------------------------------------TGALAAAKVIE--TKSEEE----------------------------LEDYIVEIEILATC--------------------------DHPYIVKLLGAYYHDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIMIEFCPG--------------GAVDAIMLE--LDR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHSK---------------------------------------------RIIHRDL-----KAGNVLMTL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGDIRLADFGVSAKNLKTLQK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSFIGTPYWMAPEVVMC--ETMKD-------------------------TPYD-YKADIWSLGITLIEMAQI-----------------EPPHHE--------------------------------------------------LNPMRVLLKIAKS--DPPTLLTPSKWS---------------------------------------------------------------------------------------------------VEFRDFLKIALDKNPETRPS--------------AAQLLEHPFV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
WEIV----------------GELGDGA----------------FGKVYKAKN--KE------------------------------------TGALAAAKVIE--TKSEEE----------------------------LEDYIVEIEILATC--------------------------DHPYIVKLLGAYYHDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIMIEFCPG--------------GAVDAIMLE--LDR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHSK---------------------------------------------RIIHRDL-----KAGNVLMTL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGDIRLADFGVSAKNLKTLQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPYWMAPEVVMC--ETMKD-------------------------TPYD-YKADIWSLGITLIEMAQI-----------------EPPHHE--------------------------------------------------LNPMRVLLKIAKS--DPPTLLTPSKWS---------------------------------------------------------------------------------------------------VEFRDFLKIALDKNPETRPS--------------AAQLLEHPFV
Activation segment
DFGVSAKNLKTLQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPYWMAPE
Binding pocket
GELGDGAFGKVYKAAAKVIDYIVEIEILATCDPYIVKLLGAWIMIEFCPGGAVDAIMLEFLHSKRIIHRDLKAGNVLMLADFGVS
Ligand info
Orthosteric ligand
R09
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4USE, Chain A