4UMP Chain C
Maternal embryonic leucine zipper kinase (MELK)
Inactive — 11.3%DFG-inαC-inType1.5_Back · 5QM
Resolution
2.3 Å
R-value
0.238
Predicted activity confidence11.3%
Structure info
Alternate conformationB
Missing atoms3
Missing residues3
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
MKDYDELLKYYELHETIGTAKVKLACHILTGEMVAIKIMDKNSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKGALAYAAPELIQGKGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR
UniProt reference sequence
YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWI
Aligned reference sequence
YELH----------------ETIGTGG----------------FAKVKLACH--IL------------------------------------TGEMVAIKIMD--KNTLGSD---------------------------LPRIKTEIEALKNL--------------------------RHQHICQLYHVLETAN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIFMVLEYCPG--------------GELFDYIIS--QD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLSEEETRVVFRQIVSAVAYVHSQ---------------------------------------------GYAHRDL-----KPENLLFDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YHKLKLIDFGLCAKPKGNKDY--HL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTCCGSLAYAAPELIQG--------------------------------KSYLGSEADVWSMGILLYVLMCG-----------------FLPFDD--------------------------------------------------DNVMALYKKIMRG--KYDVPKWLS------------------------------------------------------------------------------------------------------PSSILLLQQMLQVDPKKRIS--------------MKNLLNHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YELH----------------ETIGT-------------------AKVKLACH--IL------------------------------------TGEMVAIKIMD--KN---SD---------------------------LPRIKTEIEALKNL--------------------------RHQHICQLYHVLETAN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIFMVLEYCPG--------------GELFDYIIS--QD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLSEEETRVVFRQIVSAVAYVHSQ---------------------------------------------GYAHRDL-----KPENLLFDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YHKLKLIDFGLCAK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GALAYAAPELIQG--------------------------------K---GSEADVWSMGILLYVLMCG-----------------FLPFDD--------------------------------------------------DTAAALVAKIMRG--KYDVPKWLS------------------------------------------------------------------------------------------------------PSSILLLQQMLQVDPKKRIS--------------MKNLLNHPWI
Activation segment
DFGLCAK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GALAYAAPE
Binding pocket
ETIGT___AKVKLVAIKIMRIKTEIEALKNLRQHICQLYHVFMVLEYCPGGELFDYIISYVHSQGYAHRDLKPENLLFLIDFGLC
Ligand info
Orthosteric ligand
5QM
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4UMP, Chain C