4U44 Chain A
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)
Inactive — 43.7%DFG-inαC-inType1 · 3D9
Resolution
2.43 Å
R-value
0.2
Predicted activity confidence43.7%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSATFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTR
UniProt reference sequence
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI
Aligned reference sequence
FELV----------------EVVGNGT----------------YGQVYKGRH--VK------------------------------------TGQLAAIKVMD--VTEDE-----------------------------EEEIKLEINMLKKY--S-----------------------HHRNIATYYGAFIKKS--PPGHDD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVMEFCGA--------------GSITDLVKN--TKGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLKEDWIAYISREILRGLAHLHIH---------------------------------------------HVIHRDI-----KGQNVLLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAEVKLVDFGVSAQLDRTVGR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFIGTPYWMAPEVIAC--DENPD-------------------------ATYD-YRSDLWSCGITAIEMAEG-----------------APPLCD--------------------------------------------------MHPMRALFLIPRN--PPPRLKSKKWS----------------------------------------------------------------------------------------------------KKFFSFIEGCLVKNYMQRPS--------------TEQLLKHPFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FELV----------------EVVGNGT----------------YGQVYKGRH--VK------------------------------------TGQLAAIKVMD--VTEDE-----------------------------EEEIKLEINMLKKY--S-----------------------HHRNIATYYGAFIKKS-----HDD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVMEFCGA--------------GSITDLVKN--TKGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLKEDWIAYISREILRGLAHLHIH---------------------------------------------HVIHRDI-----KGQNVLLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAEVKLVDFGVSA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFIGTPYWMAPEVIAC--DENPD-------------------------ATYD-YRSDLWSCGITAIEMAEG-----------------APPLCD--------------------------------------------------MHPMRALFLIPRN--PPPRLKSKKWS----------------------------------------------------------------------------------------------------KKFFSFIEGCLVKNYMQRPS--------------TEQLLKHPFI
Activation segment
DFGVSA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFIGTPYWMAPE
Binding pocket
EVVGNGTYGQVYKAAIKVMEIKLEINMLKKYSRNIATYYGAWLVMEFCGAGSITDLVKNHLHIHHVIHRDIKGQNVLLLVDFGVS
Ligand info
Orthosteric ligand
3D9
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4U44, Chain A