4U41 Chain A
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)
Inactive — 2.4%DFG-inαC-outType1 · 3C8
Resolution
2.2 Å
R-value
0.203
Predicted activity confidence2.4%
Structure info
Alternate conformationA
Missing atoms0
Missing residues2
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
SSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEIKLEINMLKKYSHHRNIATYYGAFIKKSDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTR
UniProt reference sequence
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI
Aligned reference sequence
FELV----------------EVVGNGT----------------YGQVYKGRH--VK------------------------------------TGQLAAIKVMD--VTEDE-----------------------------EEEIKLEINMLKKY--S-----------------------HHRNIATYYGAFIKKS--PPGHDD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVMEFCGA--------------GSITDLVKN--TKGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLKEDWIAYISREILRGLAHLHIH---------------------------------------------HVIHRDI-----KGQNVLLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAEVKLVDFGVSAQLDRTVGR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFIGTPYWMAPEVIAC--DENPD-------------------------ATYD-YRSDLWSCGITAIEMAEG-----------------APPLCD--------------------------------------------------MHPMRALFLIPRN--PPPRLKSKKWS----------------------------------------------------------------------------------------------------KKFFSFIEGCLVKNYMQRPS--------------TEQLLKHPFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FELV----------------EVVGNGT----------------YGQVYKGRH--VK------------------------------------TGQLAAIKVMD--VT----------------------------------EIKLEINMLKKY--S-----------------------HHRNIATYYGAFIKKS------DD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVMEFCGA--------------GSITDLVKN--TKGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLKEDWIAYISREILRGLAHLHIH---------------------------------------------HVIHRDI-----KGQNVLLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAEVKLVDFG-------------R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFIGTPYWMAPEVIAC--DENPD-------------------------ATYD-YRSDLWSCGITAIEMAEG-----------------APPLCD--------------------------------------------------MHPMRALFLIPRN--PPPRLKSKKWS----------------------------------------------------------------------------------------------------KKFFSFIEGCLVKNYMQRPS--------------TEQLLKHPFI
Activation segment
DFG-------------R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFIGTPYWMAPE
Binding pocket
EVVGNGTYGQVYKAAIKVMEIKLEINMLKKYSRNIATYYGAWLVMEFCGAGSITDLVKNHLHIHHVIHRDIKGQNVLLLVDFG__
Ligand info
Orthosteric ligand
3C8
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4U41, Chain A