4U0I Chain A
Mast/stem cell growth factor receptor Kit (KIT)
Inactive — 0.0%DFG-outαC-inType2 · 0LI
Resolution
2.0 Å
R-value
0.204
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSLALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTN
UniProt reference sequence
LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEK
Aligned reference sequence
LSFG----------------KTLGAGA----------------FGKVVEATA--YGLIKSD-------------------------------AAMTVAVKMLK--PSAHLTE---------------------------REALMSELKVLSYL--G-----------------------NHMNIVNLLGACTIGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVITEYCCY--------------GDLLNFLRR--KRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDEL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDLEDLLSFSYQVAKGMAFLASK---------------------------------------------NCIHRDL-----AARNILLTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRITKICDFGLARDIKNDSNY--VVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPESIFN--------------------------------CVYT-FESDVWSYGIFLWELFSL--G--------------SSPYPG--M-----------------------------------------------PVDSKFYKMIKEG--FRMLSPEHAP-----------------------------------------------------------------------------------------------------AEMYDIMKTCWDADPLKRPT--------------FKQIVQLIEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LSFG----------------KTLGAGA----------------FGKVVEATA--YGLI----------------------------------AAMTVAVKMLK--PSAHLTE---------------------------REALMSELKVLSYL--G-----------------------NHMNIVNLLGACTIGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVITEYCCY--------------GDLLNFLRR--KRDSFICS---------------------------------------------------------------------L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALDLEDLLSFSYQVAKGMAFLASK---------------------------------------------NCIHRDL-----AARNILLTH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRITKICDFGLARDIKNDSNY--VVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPESIFN--------------------------------CVYT-FESDVWSYGIFLWELFSL--G--------------SSPYPG--M-----------------------------------------------PVDSKFYKMIKEG--FRMLSPEHAP-----------------------------------------------------------------------------------------------------AEMYDIMKTCWDADPLKRPT--------------FKQIVQLIEK
Activation segment
DFGLARDIKNDSNY--VVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPE
Binding pocket
KTLGAGAFGKVVEVAVKMLALMSELKVLSYLGMNIVNLLGALVITEYCCYGDLLNFLRRFLASKNCIHRDLAARNILLICDFGLA
Ligand info
Orthosteric ligand
0LI
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4U0I, Chain A