4RVT Chain A
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)
Inactive — 2.8%DFG-inαC-outType1 · 3XM
Resolution
2.4 Å
R-value
0.212
Predicted activity confidence2.8%
Structure info
Alternate conformationB
Missing atoms10
Missing residues1
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRT
UniProt reference sequence
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI
Aligned reference sequence
FELV----------------EVVGNGT----------------YGQVYKGRH--VK------------------------------------TGQLAAIKVMD--VTEDE-----------------------------EEEIKLEINMLKKY--S-----------------------HHRNIATYYGAFIKKS--PPGHDD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVMEFCGA--------------GSITDLVKN--TKGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLKEDWIAYISREILRGLAHLHIH---------------------------------------------HVIHRDI-----KGQNVLLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAEVKLVDFGVSAQLDRTVGR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFIGTPYWMAPEVIAC--DENPD-------------------------ATYD-YRSDLWSCGITAIEMAEG-----------------APPLCD--------------------------------------------------MHPMRALFLIPRN--PPPRLKSKKWS----------------------------------------------------------------------------------------------------KKFFSFIEGCLVKNYMQRPS--------------TEQLLKHPFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FELV----------------EVVGNGT----------------YGQVYKGRH--VK------------------------------------TGQLAAIKVMD--VT---------------------------------EEIKLEINMLKKY--S-----------------------HHRNIATYYGAFIKKS--PPGHDD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVMEFCGA--------------GSITDLVKN--TKGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLKEDWIAYISREILRGLAHLHIH---------------------------------------------HVIHRDI-----KGQNVLLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAEVKLVDFGV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFIGTPYWMAPEVIAC--DENPD-------------------------ATYD-YRSDLWSCGITAIEMAEG-----------------APPLCD--------------------------------------------------MHPMRALFLIPRN--PPPRLKSKKWS----------------------------------------------------------------------------------------------------KKFFSFIEGCLVKNYMQRPS--------------TEQLLKHPFI
Activation segment
DFGV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFIGTPYWMAPE
Binding pocket
EVVGNGTYGQVYKAAIKVMEIKLEINMLKKYSRNIATYYGAWLVMEFCGAGSITDLVKNHLHIHHVIHRDIKGQNVLLLVDFGV_
Ligand info
Orthosteric ligand
3XM
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4RVT, Chain A