4RED Chain A
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
Inactive — 0.1%DFG-inαC-out
Resolution
2.95 Å
R-value
0.233
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
SVKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKIFYTPQYLNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSTTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS
UniProt reference sequence
YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWF
Aligned reference sequence
YILG----------------DTLGVGT----------------FGKVKVGKH--EL------------------------------------TGHKVAVKILN--RQKIRSLDV-------------------------VGKIRREIQNLKLF--------------------------RHPHIIKLYQVISTPS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIFMVMEYVSG--------------GELFDYICK--NG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLDEKESRRLFQQILSGVDYCHRH---------------------------------------------MVVHRDL-----KPENVLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMNAKIADFGLSNMMSDGEFL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTSCGSPNYAAPEVISG--------------------------------RLYAGPEVDIWSSGVILYALLCG-----------------TLPFDD--------------------------------------------------DHVPTLFKKICDG--IFYTPQYLN------------------------------------------------------------------------------------------------------PSVISLLKHMLQVDPMKRAT--------------IKDIREHEWF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YILG----------------DTLGVGT----------------FGKVKVGKH--EL------------------------------------TGHAVAVKILN--RQKIRSLDV-------------------------VGKIRREIQNLKLF--------------------------RHPHIIKLYQVISTPS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIFMVMEYVSG--------------GELFDYICK--NG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLDEKESRRLFQQILSGVDYCHRH---------------------------------------------MVVHRDL-----KPENVLLDA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMNAKIADFGLSNMMSD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPNYAAPEVISG--------------------------------RLYAGPEVDIWSSGVILYALLCG-----------------TLPFDD--------------------------------------------------DHVPTLFKK------IFYTPQYLN------------------------------------------------------------------------------------------------------PSVISLLKHMLQVDPMKRAS--------------IKDIREHEWF
Activation segment
DFGLSNMMSD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPNYAAPE
Binding pocket
DTLGVGTFGKVKVVAVKILKIRREIQNLKLFRPHIIKLYQVFMVMEYVSGGELFDYICKYCHRHMVVHRDLKPENVLLIADFGLS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4RED, Chain A