4RA5 Chain A
Protein kinase C theta type (PRKCQ)
Active — 94.6%DFG-inαC-inType1 · 3L0
Resolution
2.61 Å
R-value
0.23
Predicted activity confidence94.6%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLFADRALINSMDQNMFRNFFMNPGMERLISH
UniProt reference sequence
FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLF
Aligned reference sequence
FILH----------------KMLGKGS----------------FGKVFLAEF--KK------------------------------------TNQFFAIKALK--KDVVLMDDD-------------------------VECTMVEKRVLSLA--W-----------------------EHPFLTHMFCTFQTKE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLFFVMEYLNG--------------GDLMYHIQS--CH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFDLSRATFYAAEIILGLQFLHSK---------------------------------------------GIVYRDL-----KLDNILLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKIADFGMCKENMLGDAK--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFCGTPDYIAPEILLG--------------------------------QKYN-HSVDWWSFGVLLYEMLIG-----------------QSPFHG--------------------------------------------------QDEEELFHSIRMD--NPFYPRWLE------------------------------------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG--V-----------RGDIRQHPLF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FELH----------------KMLGKGS----------------FGKVFLAEF--KK------------------------------------TNQFFAIKALK--KDVVLMDDD-------------------------VECTMVEKRVLSLA--W-----------------------EHPFLTHMFCTFQTKE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLFFVMEYLNG--------------GDLMYHIQS--CH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFDLSRATFYAAEIILGLQFLHSK---------------------------------------------GIVYRDL-----KLDNILLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKIADFGMCKENMLGDAK--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEFCGTPDYIAPEILLG--------------------------------QKYN-HSVDWWSFGVLLYEMLIG-----------------QSPFHG--------------------------------------------------QDEEELFHSIRMD--NPFYPRWLE------------------------------------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG--V-----------RGDIRQHPLF
Activation segment
DFGMCKENMLGDAK--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEFCGTPDYIAPE
Binding pocket
KMLGKGSFGKVFLFAIKALCTMVEKRVLSLAWPFLTHMFCTFFVMEYLNGGDLMYHIQSFLHSKGIVYRDLKLDNILLIADFGMC
Ligand info
Orthosteric ligand
3L0
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4RA5, Chain A