4RA4 Chain A
Protein kinase C alpha type (PRKCA)
Active — 83.7%DFG-inαC-inType1 · 3KZ
Resolution
2.63 Å
R-value
0.19
Predicted activity confidence83.7%
Structure info
Alternate conformation—
Missing atoms4
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKGQPVLPPDQLVIANIDQSDFEGFYVNPQFVHP
UniProt reference sequence
FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFF
Aligned reference sequence
FNFL----------------MVLGKGS----------------FGKVMLADR--KG------------------------------------TEELYAIKILK--KDVVIQDDD-------------------------VECTMVEKRVLALL--D-----------------------KPPFLTQLHSCFQTVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLYFVMEYVNG--------------GDLMYHIQQ--VG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFKEPQAVFYAAEISIGLFFLHKR---------------------------------------------GIIYRDL-----KLDNVMLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHIKIADFGMCKEHMMDGVT--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTFCGTPDYIAPEIIAY--------------------------------QPYG-KSVDWWAYGVLLYEMLAG-----------------QPPFDG--------------------------------------------------EDEDELFQSIMEH--NVSYPKSLS------------------------------------------------------------------------------------------------------KEAVSVCKGLMTKHPAKRLG--CGPEG-------ERDVREHAFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FNFL----------------MVLGKGS----------------FGKVMLADR--KG------------------------------------TEELYAIKILK--KDVVIQDDD-------------------------VECTMVEKRVLALL--D-----------------------KPPFLTQLHSCFQTVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLYFVMEYVNG--------------GDLMYHIQQ--VG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFKEPQAVFYAAEISIGLFFLHKR---------------------------------------------GIIYRDL-----KLDNVMLDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHIKIADFGMCKEHMMDGVT--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-FCGTPDYIAPEIIAY--------------------------------QPYG-KSVDWWAYGVLLYEMLAG-----------------QPPFDG--------------------------------------------------EDEDELFQSIMEH--NVSYPKSLS------------------------------------------------------------------------------------------------------KEAVSICKGLMTKHPAKRLG--CGPEG-------ERDVREHAFF
Activation segment
DFGMCKEHMMDGVT--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-FCGTPDYIAPE
Binding pocket
MVLGKGSFGKVMLYAIKILCTMVEKRVLALLDPFLTQLHSCYFVMEYVNGGDLMYHIQQFLHKRGIIYRDLKLDNVMLIADFGMC
Ligand info
Orthosteric ligand
3KZ
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4RA4, Chain A