4R6V Chain A
Fibroblast growth factor receptor 4 (FGFR4)
Inactive — 0.0%DFG-outαC-inType1.5_Back · FI3
Resolution
2.35 Å
R-value
0.179
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DPLLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVILECAAKGNLREFLRARRPPGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLAPVKWMAPEALFDEVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV
UniProt reference sequence
LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDK
Aligned reference sequence
LVLG----------------KPLGEGC----------------FGQVVRAEA--FGMDPARPD-----------------------------QASTVAVKMLK--DNASDKD---------------------------LADLVSEMEVMKLI--G-----------------------RHKNIINLLGVCTQEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVIVECAAK--------------GNLREFLRA--RRPPGPDLSPDGPRSSEG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSFPVLVSCAYQVARGMQYLESR---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGLARGVHHIDYY--KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNGRLPVKWMAPEALFD--------------------------------RVYT-HQSDVWSFGILLWEIFTL--G--------------GSPYPG--------------------------------------------------IPVEELFSLLREG--HRMDRPPHCP-----------------------------------------------------------------------------------------------------PELYGLMRECWHAAPSQRPT--------------FKQLVEALDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LVLG----------------KPLGEGC----------------FGQVVRAEA--FGM-----D-----------------------------QASTVAVKMLK--DNASDKD---------------------------LADLVSEMEVMKLI--G-----------------------RHKNIINLLGVCTQEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVILECAAK--------------GNLREFLRA--RRPP-------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSFPVLVSCAYQVARGMQYLESR---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGLA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVKWMAPEALFD--------------------------------EVYT-HQSDVWSFGILLWEIFTL--G--------------GSPYPG--------------------------------------------------IPVEELFSLLREG--HRMDRPPHCP-----------------------------------------------------------------------------------------------------PELYGLMRECWHAAPSQRPT--------------FKQLVEALDK
Activation segment
DFGLA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVKWMAPE
Binding pocket
KPLGEGCFGQVVRVAVKMLDLVSEMEVMKLIGKNIINLLGVYVILECAAKGNLREFLRAYLESRKCIHRDLAARNVLVIADFGLA
Ligand info
Orthosteric ligand
FI3
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4R6V, Chain A