4Q9Z Chain B
Protein kinase C theta type (PRKCQ)
Active — 91.9%DFG-inαC-inType1 · PZW
Resolution
2.6 Å
R-value
0.22
Predicted activity confidence91.9%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKNMFRNFFMNPGMERL
UniProt reference sequence
FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLF
Aligned reference sequence
FILH----------------KMLGKGS----------------FGKVFLAEF--KK------------------------------------TNQFFAIKALK--KDVVLMDDD-------------------------VECTMVEKRVLSLA--W-----------------------EHPFLTHMFCTFQTKE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLFFVMEYLNG--------------GDLMYHIQS--CH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFDLSRATFYAAEIILGLQFLHSK---------------------------------------------GIVYRDL-----KLDNILLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKIADFGMCKENMLGDAK--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFCGTPDYIAPEILLG--------------------------------QKYN-HSVDWWSFGVLLYEMLIG-----------------QSPFHG--------------------------------------------------QDEEELFHSIRMD--NPFYPRWLE------------------------------------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG--V-----------RGDIRQHPLF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FELH----------------KMLGKGS----------------FGKVFLAEF--KK------------------------------------TNQFFAIKALK--KDVVLMDDD-------------------------VECTMVEKRVLSLA--W-----------------------EHPFLTHMFCTFQTKE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLFFVMEYLNG--------------GDLMYHIQS--CH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFDLSRATFYAAEIILGLQFLHSK---------------------------------------------GIVYRDL-----KLDNILLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKIADFGMCKENMLGDAK--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEFCGTPDYIAPEILLG--------------------------------QKYN-HSVDWWSFGVLLYEMLIG-----------------QSPFHG--------------------------------------------------QDEEELFHSIRMD--NPFYPRWLE------------------------------------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG--V-----------RGDIRQHPLF
Activation segment
DFGMCKENMLGDAK--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEFCGTPDYIAPE
Binding pocket
KMLGKGSFGKVFLFAIKALCTMVEKRVLSLAWPFLTHMFCTFFVMEYLNGGDLMYHIQSFLHSKGIVYRDLKLDNILLIADFGMC
Ligand info
Orthosteric ligand
PZW
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4Q9Z, Chain B