4PWN Chain A
Serine/threonine-protein kinase WNK1 (WNK1)
Inactive — 0.0%DFG-inαC-out
Resolution
1.84 Å
R-value
0.231
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
KAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDFKEEAEMLKGLQHPNIVRFYDSWESTCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEE
UniProt reference sequence
FLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFF
Aligned reference sequence
FLKF--D-------------IEIGRGS----------------FKTVYKGLD--TE------------------------------------TTVEVAWCELQ--DRKLTKSE--------------------------RQRFKEEAEMLKGL--------------------------QHPNIVRFYDSWESTV--KGKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CIVLVTELMTS--------------GTLKTYLKR--FK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VMKIKVLRSWCRQILKGLQFLHTR--TP-----------------------------------------PIIHRDL-----KCDNIFITG--P-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGSVKIGDLGLATLKRASFA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSVIGTPEFMAPEMYE---------------------------------EKYD-ESVDVYAFGMCMLEMATS-----------------EYPYSE--C-----------------------------------------------QNAAQIYRRVTSG--VKPASFDKVAI----------------------------------------------------------------------------------------------------PEVKEIIEGCIRQNKDERYS--------------IKDLLNHAFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FLKF--D-------------IEIGRGS----------------FKTVYKGLD--TE------------------------------------TTVEVAWCELQ--D------------------------------------FKEEAEMLKGL--------------------------QHPNIVRFYDSWEST---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CIVLVTELMTS--------------GTLKTYLKR--FK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VMKIKVLRSWCRQILKGLQFLHTR--TP-----------------------------------------PIIHRDL-----KCDNIFITG--P-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGSVKIGDLGLATL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFMAPEMYE---------------------------------EKYD-ESVDVYAFGMCMLEMATS-----------------EYPYSE--C-----------------------------------------------QNAAQIYRRVTSG--VKPASFDKVAI----------------------------------------------------------------------------------------------------PEVKEIIEGCIRQNKDERYS--------------IKDLLNHAFF
Activation segment
DLGLATL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFMAPE
Binding pocket
IEIGRGSFKTVYKVAWCEL_FKEEAEMLKGLQPNIVRFYDSVLVTELMTSGTLKTYLKRHTRTPPIIHRDLKCDNIFIIGDLGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4PWN, Chain A