4PRJ Chain A
Aurora kinase A (AURKA)
Inactive — 42.0%DFG-inαC-inType1 · 2VU
Resolution
2.8 Å
R-value
0.233
Predicted activity confidence42.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues3
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KRQWALEDFEIGRPLGKGNVYLAREKNSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDSTRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKKVIHRDIKPENLLLGSAGELKIADFGWSVCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQDTYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSS
UniProt reference sequence
FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI
Aligned reference sequence
FEIG----------------RPLGKGK----------------FGNVYLARE--KQ------------------------------------SKFILALKVLF--KAQLEKAGV-------------------------EHQLRREVEIQSHL--------------------------RHPNILRLYGYFHDAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVYLILEYAPL--------------GTVYRELQK--LS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK---------------------------------------------RVIHRDI-----KPENLLLGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGELKIADFGWSVHAPSSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTLCGTLDYLPPEMIEG--------------------------------RMHD-EKVDLWSLGVLCYEFLVG-----------------KPPFEA--------------------------------------------------NTYQETYKRISRV--EFTFPDFVT------------------------------------------------------------------------------------------------------EGARDLISRLLKHNPSQRPM--------------LREVLEHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEIG----------------RPLGK-------------------GNVYLARE--KN------------------------------------SKFILALKVLF--KAQLEKAGV-------------------------EHQLRREVEIQSHL--------------------------RHPNILRLYGYFHDST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVYLILEYAPL--------------GTVYRELQK--LS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK---------------------------------------------KVIHRDI-----KPENLLLGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGELKIADFGWSV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGTLDYLPPEMIEG--------------------------------RMHD-EKVDLWSLGVLCYEFLVG-----------------KPPFEA--------------------------------------------------NTYQDTYKRISRV--EFTFPDFVT------------------------------------------------------------------------------------------------------EGARDLISRLLKHNPSQRPM--------------LREVLEHPWI
Activation segment
DFGWSV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGTLDYLPPE
Binding pocket
RPLGKG___NVYLLALKVLQLRREVEIQSHLRPNILRLYGYYLILEYAPLGTVYRELQKYCHSKKVIHRDIKPENLLLIADFGWS
Ligand info
Orthosteric ligand
2VU
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4PRJ, Chain A