4P90 Chain A
Serine/threonine-protein kinase PAK 1 (PAK1)
Active — 98.9%DFG-inαC-inType1 · 2K0
Resolution
2.49 Å
R-value
0.209
Predicted activity confidence98.9%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
DEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMEVAIKQMKELIINEILVMRENKNPNIVNYLDSYLELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRNIKSDNILLGMDGSVKLTDFGFCAQIKRSEMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLDMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK
UniProt reference sequence
YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFL
Aligned reference sequence
YTRF----------------EKIGQGA----------------SGTVYTAMD--VA------------------------------------TGQEVAIKQMN--LQQQPK----------------------------KELIINEILVMREN--------------------------KNPNIVNYLDSYLVGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVVMEYLAG--------------GSLTDVVTE--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CMDEGQIAAVCRECLQALEFLHSN---------------------------------------------QVIHRDI-----KSDNILLGM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGSVKLTDFGFCAQITPEQSK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STMVGTPYWMAPEVVTR--------------------------------KAYG-PKVDIWSLGIMAIEMIEG-----------------EPPYLN--------------------------------------------------ENPLRALYLIATN--GTPELQNPEKLS---------------------------------------------------------------------------------------------------AIFRDFLNRCLEMDVEKRGS--------------AKELLQHQFL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YTRF----------------EKIGQGA----------------SGTVYTAM--------------------------------------------EVAIKQM-------------------------------------KELIINEILVMREN--------------------------KNPNIVNYLDSYL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELWVVMEYLAG--------------GSLTDVVTE--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CMDEGQIAAVCRECLQALEFLHSN---------------------------------------------QVIHRNI-----KSDNILLGM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGSVKLTDFGFCAQI-----K--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEMVGTPYWMAPEVVTR--------------------------------KAYG-PKVDIWSLGIMAIEMIEG-----------------EPPYLN--------------------------------------------------ENPLRALYLIATN--GTPELQNPEKLS---------------------------------------------------------------------------------------------------AIFRDFLNRCLDMDVEKRGS--------------AKELLQHQFL
Activation segment
DFGFCAQI-----K--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEMVGTPYWMAPE
Binding pocket
EKIGQGASGTVYTVAIKQMLIINEILVMRENKPNIVNYLDSWVVMEYLAGGSLTDVVTEFLHSNQVIHRNIKSDNILLLTDFGFC
Ligand info
Orthosteric ligand
2K0
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4P90, Chain A