4OTG Chain A
Serine/threonine-protein kinase N1 (PKN1)
Active — 99.3%DFG-inαC-inType1 · 2V9
Resolution
2.6 Å
R-value
0.212
Predicted activity confidence99.3%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLFTGEAPTLPPRDARPLTAAEQAAFLDFDFVAG
UniProt reference sequence
FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF
Aligned reference sequence
FKFL----------------AVLGRGH----------------FGKVLLSEF--RP------------------------------------SGELFAIKALK--KGDIVARDE-------------------------VESLMCEKRILAAV--TSA---------------------GHPFLVNLFGCFQTPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVCFVMEYSAG--------------GDLMLHIHS--D--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFSEPRAIFYSACVVLGLQFLHEH---------------------------------------------KIVYRDL-----KLDNLLLDT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGYVKIADFGLCKEGMGYGDR--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STFCGTPEFLAPEVLTD--------------------------------TSYT-RAVDWWGLGVLLYEMLVG-----------------ESPFPG--------------------------------------------------DDEEEVFDSIVND--EVRYPRFLS------------------------------------------------------------------------------------------------------AEAIGIMRRLLRRNPERRLG--SSERD-------AEDVKKQPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKFL----------------AVLGRGH----------------FGKVLLSEF--RP------------------------------------SGELFAIKALK--KGDIVARDE-------------------------VESLMCEKRILAAV--TSA---------------------GHPFLVNLFGCFQTPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVCFVMEYSAG--------------GDLMLHIHS--D--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFSEPRAIFYSACVVLGLQFLHEH---------------------------------------------KIVYRDL-----KLDNLLLDT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGYVKIADFGLCKEGMGYGDR--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-FCGTPEFLAPEVLTD--------------------------------TSYT-RAVDWWGLGVLLYEMLVG-----------------ESPFPG--------------------------------------------------DDEEEVFDSIVND--EVRYPRFLS------------------------------------------------------------------------------------------------------AEAIGIMRRLLRRNPERRLG--SSERD-------AEDVKKQPFF
Activation segment
DFGLCKEGMGYGDR--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-FCGTPEFLAPE
Binding pocket
AVLGRGHFGKVLLFAIKALSLMCEKRILAAVTPFLVNLFGCCFVMEYSAGGDLMLHIHSFLHEHKIVYRDLKLDNLLLIADFGLC
Ligand info
Orthosteric ligand
2V9
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4OTG, Chain A