4OTD Chain A
Serine/threonine-protein kinase N1 (PKN1)
Active — 99.1%DFG-inαC-in
Resolution
2.0 Å
R-value
0.177
Predicted activity confidence99.1%
Structure info
Alternate conformationA
Missing atoms11
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLPPRDARPLTAAEQAAFLDFDFVAG
UniProt reference sequence
FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF
Aligned reference sequence
FKFL----------------AVLGRGH----------------FGKVLLSEF--RP------------------------------------SGELFAIKALK--KGDIVARDE-------------------------VESLMCEKRILAAV--TSA---------------------GHPFLVNLFGCFQTPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVCFVMEYSAG--------------GDLMLHIHS--D--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFSEPRAIFYSACVVLGLQFLHEH---------------------------------------------KIVYRDL-----KLDNLLLDT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGYVKIADFGLCKEGMGYGDR--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STFCGTPEFLAPEVLTD--------------------------------TSYT-RAVDWWGLGVLLYEMLVG-----------------ESPFPG--------------------------------------------------DDEEEVFDSIVND--EVRYPRFLS------------------------------------------------------------------------------------------------------AEAIGIMRRLLRRNPERRLG--SSERD-------AEDVKKQPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKFL----------------AVLGRGH----------------FGKVLLSEF--RP------------------------------------SGELFAIKALK--KGDIVARDE-------------------------VESLMCEKRILAAV--TSA---------------------GHPFLVNLFGCFQTPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVCFVMEYSAG--------------GDLMLHIHS--D--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFSEPRAIFYSACVVLGLQFLHEH---------------------------------------------KIVYRDL-----KLDNLLLDT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGYVKIADFGLCKEGMGYGDR--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-FCGTPEFLAPEVLTD--------------------------------TSYT-RAVDWWGLGVLLYEMLVG-----------------ESPFPG--------------------------------------------------DDEEEVFDSIVND--EVRYPRFLS------------------------------------------------------------------------------------------------------AEAIGIMRRLLRRNPERRLG--SSERD-------AEDVKKQPFF
Activation segment
DFGLCKEGMGYGDR--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-FCGTPEFLAPE
Binding pocket
AVLGRGHFGKVLLFAIKALSLMCEKRILAAVTPFLVNLFGCCFVMEYSAGGDLMLHIHSFLHEHKIVYRDLKLDNLLLIADFGLC
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4OTD, Chain A