4OBP Chain A
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)
Inactive — 42.5%DFG-inαC-inType1 · 2QU
Resolution
2.27 Å
R-value
0.206
Predicted activity confidence42.5%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
IDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSANTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTR
UniProt reference sequence
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI
Aligned reference sequence
FELV----------------EVVGNGT----------------YGQVYKGRH--VK------------------------------------TGQLAAIKVMD--VTEDE-----------------------------EEEIKLEINMLKKY--S-----------------------HHRNIATYYGAFIKKS--PPGHDD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVMEFCGA--------------GSITDLVKN--TKGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLKEDWIAYISREILRGLAHLHIH---------------------------------------------HVIHRDI-----KGQNVLLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAEVKLVDFGVSAQLDRTVGR--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFIGTPYWMAPEVIAC--DENPD-------------------------ATYD-YRSDLWSCGITAIEMAEG-----------------APPLCD--------------------------------------------------MHPMRALFLIPRN--PPPRLKSKKWS----------------------------------------------------------------------------------------------------KKFFSFIEGCLVKNYMQRPS--------------TEQLLKHPFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FELV----------------EVVGNGT----------------YGQVYKGRH--VK------------------------------------TGQLAAIKVMD--VTEDE-----------------------------EEEIKLEINMLKKY--S-----------------------HHRNIATYYGAFIKKS------DD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVMEFCGA--------------GSITDLVKN--TKGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLKEDWIAYISREILRGLAHLHIH---------------------------------------------HVIHRDI-----KGQNVLLTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAEVKLVDFGVSA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFIGTPYWMAPEVIAC--DENPD-------------------------ATYD-YRSDLWSCGITAIEMAEG-----------------APPLCD--------------------------------------------------MHPMRALFLIPRN--PPPRLKSKKWS----------------------------------------------------------------------------------------------------KKFFSFIEGCLVKNYMQRPS--------------TEQLLKHPFI
Activation segment
DFGVSA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFIGTPYWMAPE
Binding pocket
EVVGNGTYGQVYKAAIKVMEIKLEINMLKKYSRNIATYYGAWLVMEFCGAGSITDLVKNHLHIHHVIHRDIKGQNVLLLVDFGVS
Ligand info
Orthosteric ligand
2QU
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4OBP, Chain A