4OAV Chain D
2-5A-dependent ribonuclease (RNASEL)
Inactive — 0.3%DFG-inαC-inATPlike · ACP
Resolution
2.1 Å
R-value
0.2
Predicted activity confidence0.3%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
NHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVNEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGENIDEMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQT
UniProt reference sequence
LKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF
Aligned reference sequence
LKFF--IDEK----------YKIADTS----------------EGGIYLGFY----------------------------------------EKQEVAVKTFC--EG--------------------------------SPRAQREVSCLQSS--R-----------------------ENSHLVTFYGSESHRG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLFVCVTLCE---------------QTLEACLDV--HRGEDVE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEEDEFARNVLSSIFKAVQELHLS--C------------------------------------------GYTHQDL-----QPQNILIDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKAAHLADFDKSIKWAGD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQE-VKRDLEDLGRLVLYVVKK----------------------------------------------------------------------------------------GSISFEDLKAQSNEEVVQLSPD-----------------------------------------------------------------------------------------EETKDLIHRLFHPGEHVRDC--------------LSDLLGHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKFF--IDEK----------YKIADTS----------------EGGIYLGFY----------------------------------------EKQEVAVKTFC--EG--------------------------------SPRAQREVSCLQSS--R-----------------------ENSHLVTFYGSESHRG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLFVCVTLCE---------------QTLEACLDV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEEDEFARNVLSSIFKAVQELHLS--C------------------------------------------GYTHQDL-----QPQNILIDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKAAHLADFDKSIKWAGD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQE-VKRDLEDLGRLVLYVVKK----------------------------------------------------------------------------------------GSISFEDLKAQSNEEVVQLSPD-----------------------------------------------------------------------------------------EETKDLIHRLFHPGEHVRDC--------------LSDLLGHPFF
Activation segment
DFDKSIKWAGD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Binding pocket
YKIADTSEGGIYLVAVKTFRAQREVSCLQSSRSHLVTFYGSFVCVTLCEQ_TLEACLDVLHLSCGYTHQDLQPQNILILADFDKS
Ligand info
Orthosteric ligand
ACP
Allosteric ligand
PUP
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4OAV, Chain D