4OAU Chain C
2-5A-dependent ribonuclease (RNASEL)
Inactive — 2.4%DFG-inαC-inATPlike · ADP
Resolution
2.6 Å
R-value
0.213
Predicted activity confidence2.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGENIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQT
UniProt reference sequence
LKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF
Aligned reference sequence
LKFF--IDEK----------YKIADTS----------------EGGIYLGFY----------------------------------------EKQEVAVKTFC--EG--------------------------------SPRAQREVSCLQSS--R-----------------------ENSHLVTFYGSESHRG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLFVCVTLCE---------------QTLEACLDV--HRGEDVE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEEDEFARNVLSSIFKAVQELHLS--C------------------------------------------GYTHQDL-----QPQNILIDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKAAHLADFDKSIKWAGD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQE-VKRDLEDLGRLVLYVVKK----------------------------------------------------------------------------------------GSISFEDLKAQSNEEVVQLSPD-----------------------------------------------------------------------------------------EETKDLIHRLFHPGEHVRDC--------------LSDLLGHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKFF--IDEK----------YKIADTS----------------EGGIYLGFY----------------------------------------EKQEVAVKTFC--EG--------------------------------SPRAQREVSCLQSS--R-----------------------ENSHLVTFYGSESHRG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLFVCVTLCE---------------QTLEACLDV--HRGEDVE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEEDEFARNVLSSIFKAVQELHLS--C------------------------------------------GYTHQDL-----QPQNILIDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKAAHLADFDKSIKWAGD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQE-VKRDLEDLGRLVLYVVKK----------------------------------------------------------------------------------------GSISFEDLKAQSNEEVVQLSPD-----------------------------------------------------------------------------------------EETKDLIHRLFHPGEHVRDC--------------LSDLLGHPFF
Activation segment
DFDKSIKWAGD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Binding pocket
YKIADTSEGGIYLVAVKTFRAQREVSCLQSSRSHLVTFYGSFVCVTLCEQ_TLEACLDVLHLSCGYTHQDLQPQNILILADFDKS
Ligand info
Orthosteric ligand
ADP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4OAU, Chain C