4NKS Chain B
Fibroblast growth factor receptor 1 (FGFR1)
Inactive — 0.0%DFG-inαC-inType1 · 2M2
Resolution
2.5 Å
R-value
0.223
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms16
Missing residues1
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SEYELPEDPRWELPRDRLVLGKPLGEGAGQVVLAEAIGLPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLADYYKKGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT
UniProt reference sequence
LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR
Aligned reference sequence
LVLG----------------KPLGEGC----------------FGQVVLAEA--IGLDKDKPN-----------------------------RVTKVAVKMLK--SDATEKD---------------------------LSDLISEMEMMKMI--G-----------------------KHKNIINLLGACTQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVIVEYASK--------------GNLREYLQA--RRPPGLEYCYNPSHNPEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLSSKDLVSCAYQVARGMEYLASK---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGLARDIHHIDYY--KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGRLPVKWMAPEALFD--------------------------------RIYT-HQSDVWSFGVLLWEIFTL--G--------------GSPYPG--------------------------------------------------VPVEELFKLLKEG--HRMDKPSNCT-----------------------------------------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT--------------FKQLVEDLDR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LVLG----------------KPLGEG-----------------AGQVVLAEA--IGL----PN-----------------------------RVTKVAVKMLK--SDATEKD---------------------------LSDLISEMEMMKMI--G-----------------------KHKNIINLLGACTQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVIVEYASK--------------GNLREYLQA--RR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLSSKDLVSCAYQVARGMEYLASK---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGLA------DYY--KK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRLPVKWMAPEALFD--------------------------------RIYT-HQSDVWSFGVLLWEIFTL--G--------------GSPYPG--------------------------------------------------VPVEELFKLLKEG--HRMDKPSNCT-----------------------------------------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT--------------FKQLVEDLDR
Activation segment
DFGLA------DYY--KK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRLPVKWMAPE
Binding pocket
KPLGEGA_GQVVLVAVKMLDLISEMEMMKMIGKNIINLLGAYVIVEYASKGNLREYLQAYLASKKCIHRDLAARNVLVIADFGLA
Ligand info
Orthosteric ligand
2M2
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4NKS, Chain B