4MXZ Chain B
Proto-oncogene tyrosine-protein kinase Src (SRC)
Inactive — 5.3%DFG-inαC-inType1 · DB8
Resolution
2.58 Å
R-value
0.211
Predicted activity confidence5.3%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVLKKLRHEKLVQLYAVVSEEPIYIVMEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
UniProt reference sequence
LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLED
Aligned reference sequence
LRLE----------------VKLGQGC----------------FGEVWMGTW--N-------------------------------------GTTRVAIKTLK--PGTMS-----------------------------PEAFLQEAQVMKKL--------------------------RHEKLVQLYAVVSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVTEYMSK--------------GSLLDFLKG--ETGK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLRLPQLVDMAAQIASGMAYVERM---------------------------------------------NYVHRDL-----RAANILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVADFGLARLIEDNEYT--AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGAKFPIKWTAPEAALY--------------------------------GRFT-IKSDVWSFGILLTELTTK--G--------------RVPYPG--------------------------------------------------MVNREVLDQVERG--YRMPCPPECP-----------------------------------------------------------------------------------------------------ESLHDLMCQCWRKEPEERPT--------------FEYLQAFLED
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LRLE----------------VKLGQGC----------------FGEVWMGTW--N-------------------------------------GTTRVAIKTLK--PGTMS-----------------------------PEAFLQEAQVLKKL--------------------------RHEKLVQLYAVVSEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIYIVMEYMSK--------------GSLLDFLKG--ETGK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLRLPQLVDMAAQIASGMAYVERM---------------------------------------------NYVHRDL-----RAANILVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVADFGLARLI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPIKWTAPEAALY--------------------------------GRFT-IKSDVWSFGILLTELTTK--G--------------RVPYPG--------------------------------------------------MVNREVLDQVERG--YRMPCPPECP-----------------------------------------------------------------------------------------------------ESLHDLMCQCWRKEPEERPT--------------FEYLQAFLED
Activation segment
DFGLARLI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPIKWTAPE
Binding pocket
VKLGQGCFGEVWMVAIKTLAFLQEAQVLKKLREKLVQLYAVYIVMEYMSKGSLLDFLKGYVERMNYVHRDLRAANILVVADFGLA
Ligand info
Orthosteric ligand
DB8
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4MXZ, Chain B