4M69 Chain B
Mixed lineage kinase domain-like protein (MLKL)
Inactive — 5.9%DFG-inαC-in
Resolution
2.5 Å
R-value
0.222
Predicted activity confidence5.9%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
QIKEIPKEHLGPPWTKLKTSKMSTIYRGEYHRSPVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILERLSAVEE
UniProt reference sequence
LSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLST
Aligned reference sequence
LSGS--PW------------ILLRENE----------------VSTLYKGEY----------------------------------------HRAPVAIKVFK--KLQAGSIAIV------------------------RQTFNKEIKTMKKF--------------------------ESPNILRIFGICIDET--VTPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFSIVMEYCEL--------------GTLRELLDR--EK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTLGKRMVLVLGAARGLYRLHHS--EA-----------------------------------------PELHGKI-----RSSNFLVTQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GYQVKLAGFELRKTQTSMSLG--TTREK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDRVKSTAYLSPQELED--VF----------------------------YQYD-VKSEIYSFGIVLWEIATG-----------------DIPFQG--------------------------------------------------CNSEKIRKLVAVK--RQQEPLGEDCP----------------------------------------------------------------------------------------------------SELREIIDECRAHDPSVRPS--------------VDEILKKLST
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
HLGP--PW------------TKLKTSK----------------MSTIYRGEY----------------------------------------HRSPVTIKVFN--NPQAESVGIV------------------------RFTFNDEIKTMKKF--------------------------DSPNILRIFGICIDQT--VKPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFSIVMEYCEL--------------GTLRELLDR--EK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLTMSVRSLLVLRAARGLYRLHHS--E-------------------------------------------TLHRNI-----SSSSFLVAG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GYQVKLAGFELSKTQNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSTIYVSPERLKN--PF----------------------------CLYD-IKAEIYSFGIVLWEIATG-----------------KIPFEG--------------------------------------------------CDSKKIRELVAED--KKQEPVGQDCP----------------------------------------------------------------------------------------------------ELLREIINECRAHEPSQRPS--------------VDGILERLSE
Activation segment
GFELSKTQNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSTIYVSPE
Binding pocket
TKLKTSKMSTIYRVTIKVFTFNDEIKTMKKFDPNILRIFGISIVMEYCELGTLRELLDRHHSET__LHRNISSSSFLVLAGFELS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4M69, Chain B